International Journal of Drug Delivery Technology
Volume 14, Issue 3

Evaluation of the Antihyperlipidemic Effect of Encapsulated Octacosanol for Lipid-Lowering Effect Against High-Fat Diet-Induced Hyperlipidaemia in Experimental Rats

Singh AK1, Kharb R1*, Chakraborty GS2, Kandpal J B3

1Amity Institute of Pharmacy (AIP), Amity University, Noida, Uttar Pradesh, India.

2Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat, India.

3Ennature Bio Pharma Private Limited, Pharma City Selaqui Dehradun, India 

Received: 15th March, 2024; Revised: 23rd May, 2024; Accepted: 13th August, 2024; Available Online: 25th September, 2024 

ABSTRACT

Background: Elevated blood lipid levels, or hyperlipidemia, are the main risk factors for cardiovascular illnesses and are frequently brought on by high-fat diets.Objectives: In this work, high-fat diet-induced hyperlipidemia in experimental rats is used to examine the antihyperlipidemicefficacy of a test formulation containing 1-octacosanol.Method: A healthy female Wistar rat was utilized for investigation, separated into four groups: normal, disease, standard control, and test group, receiving the 1-octacosanol formulation.Results: Hyperlipidemia was induced in the rats through a high-fat diet over 28 days, followed by a 28-day treatment period. Various parameters, including lipid profile (LDL, TC, TG, VLDL, HDL), body weight and antioxidant properties (MDA, SOD, GSH), were evaluated. The results showed that the 1-octacosanol formulation significantly reduced body weight and improved lipid profiles by decreasing levels of TC, TG, LDL and VLDL while increasing HDL levels. Additionally, the formulation exhibited notable antioxidant properties, contributing to its lipid-lowering effects.Statistical analysis using ANOVA and multiple comparison tests confirmed the significance of these findings, underscoringthe therapeutic potential of 1-octacosanol in managing hyperlipidemia and mitigating associated cardiovascular risks. Conclusion: The test formulation of 1-octacosanol demonstrated a significant antihyperlipidemic effect in rats with high-fat diet-induced hyperlipidemia. The treatment effectively reduced serum levels of total cholesterol, triglycerides, LDL and VLDLwhile increasing HDL cholesterol levels. These marks suggest that 1-octacosanol has the potential as a therapeutic agent formanaging hyperlipidemia, a key risk factor for cardiovascular diseases.Keywords: 1-Octacosanol, Hyperlipidemia, Wistar rats, Cardiovascular risks, Lipid profile, Antioxidant properties.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.61

How to cite this article: Singh AK, Kharb R, Chakraborty GS, Kandpal JB. Evaluation of the Antihyperlipidemic Effect of Encapsulated Octacosanol for Lipid-Lowering Effect Against High-Fat Diet-Induced Hyperlipidaemia in Experimental Rats. International Journal of Drug Delivery Technology. 2024;14(3):1683-1693.

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