International Journal of Drug Delivery Technology
Volume 14, Issue 3

Unveiling the Multi-Targeted Mode of Action: Investigating the Antiepileptic Activity of Murraya koengii Extract in PTZ-induced Seizures

Bawankar RD1*, Kawarkhe SS2, Deshmukh SP2, Sawarkar HA3

1Agnihotri College of Pharmacy, Bapuji Wadi, Wardha, Maharashtra, India.

2Shradhha Institute of Pharmacy, Washim, Maharashtra, India.

3Anuradha College of Pharmacy, Chikhli, Buldhana, Maharashtra, India. 

Received: 20th January, 2024; Revised: 27th February, 2024; Accepted: 18th July, 2024; Available Online: 25th September, 2024 

ABSTRACT

Recurrent seizures are the hallmark of the neurological condition known as epilepsy. Murraya koenigii (curry leaves) has been traditionally used in medicine for various ailments. This study aimed at the anticonvulsant activity of HAEMK using a petylenetetrazole (PTZ) induced seizure model. Behavioral and biochemical parameters were assessed to determine the effectiveness of the extract in mitigating seizures. Albino mice were orally administered with different doses of the extract prior to PTZ administration. The behavioral parameters, including seizure latency, duration and severity, were monitored and recorded. Additionally, acetylcholine esterase, GSH, and malondialdehyde (MDA), three indicators of oxidative stress, were assessed in brain tissue homogenates. HAEMK-treated groups demonstrated a substantial increase in seizure latency and a decrease in seizure length and intensity compared to the control group. A dose-dependent MDA and acetylcholine esterase decreased concurrent GSH rise were seen in the HA-treated groups. These findings suggest that the hydroalcoholic extract ofkoenigii possesses antiepileptic activity, possibly mediated through its antioxidative mechanisms.

Keywords: Murraya koenigii, Antiepileptic activity, Behavioral parameters, Biochemical parameters, Pentylenetetrazole. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.62

How to cite this article: Bawankar RD, Kawarkhe SS, Deshmukh SP, Sawarkar HA. Unveiling the Multi-Targeted Mode of Action: Investigating the Antiepileptic Activity of Murraya koengii Extract in PTZ-induced Seizures. International Journal of Drug Delivery Technology. 2024;14(3):1694-1699.

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