International Journal of Drug Delivery Technology
Volume 14, Issue 3

Formulation, Development and Optimization of Silymarin Loaded Nanoparticle Orodispersible Tablets for its Anti-inflammatory Activity

Radhika N Kotame*, Kratika Daniel

Oriental University, Indore, Madhya Pradesh, India. 

Received: 07th March, 2024; Revised: 04th May, 2024; Accepted: 15thJuly, 2024; Available Online: 25th September, 2024 

ABSTRACT

The objective of this work was to enhance the anti-inflammatory properties of silymarin by developing and refining an orodispersible tablet formulation loaded with nanoparticles. Formulation development and optimization of silymarin-loaded nanoparticle orodispersible tablet for its anti-inflammatory activity is the focus of this research paper. Nanoparticle drug delivery systems can help to overcome these limitations by enhancing solubility and absorption. Disintegration and dissolution of Orodispersible tablets take place in the mouth rapidly without water, providing a faster onset of action. These nanoparticles were then incorporated into orodispersible tablets containing superdisintegrants and sweeteners using direct compression. A Box-Behnken design was utilized to systematically optimize the tablet formulation based on responses including disintegration time, wetting time, hardness and friability. After 15 minutes, SL-NP Formulation -3, which contains 5% crospovidone as a superdisintegrant, demonstrated maximal drug release, or 98.5%. Rats with paw edema caused by carrageenan were used to test the anti-inflammatory potential. Following three hours, the 400 mg/kg dose showed a strong 48% inhibition; the impact grew to 52% after three hours. Overall, the development of silymarin nanoparticle orodispersible tablets shows promise for improving the anti-inflammatory effects of silymarin through a synergistic combination of nanoencapsulation and rapid disintegrating tablet technologies.

Keywords: Orodispersible tablets, Rapid dissolving, Rapid disintegration, Anti-inflammatory activity, Nanoparticles. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.67

How to cite this article: Kotame RN, Daniel K. Formulation, Development and Optimization of Silymarin Loaded Nanoparticle Orodispersible Tablets for itsAnti-inflammatoryActivity. International Journal of Drug Delivery Technology. 2024;14(3):1722-1727.

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