International Journal of Drug Delivery Technology
Volume 14, Issue 3

Novel Approaches and Emerging Trends in Hydrotropic Solubilization Technology

Aliunui Aime, Harpritkaur Bagga, Gunjan Chaudhari, Ujwal Vyas*

Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education & Research (DMIHER), Deemed to be University, Wardha, Maharashtra, India. 

Received: 27th July, 2024; Revised: 12th August, 2024; Accepted: 31st August, 2024; Available Online: 25th September, 2024 

ABSTRACT

Hydrotropic solubilization technology enhances the solubility and bioavailability of poorly water-soluble drugs, a major challenge in pharmaceutical research. This review discusses hydrotropic agents’ structures, the solubilization process, and factors affecting drug solubility. It explores optimizing agent concentrations, the role of computer modeling and QSAR studies, and hydrotropes’ impact on overcoming biological barriers and improving pharmacokinetics and pharmacodynamics. The review highlights hydrotropic compounds’ potential in advancing pharmaceutical formulations and clinical applications.

Keywords: Hydrotropic solubilization, Bioavailability, Poorly water-soluble drugs, Pharmacokinetics, Quantitative structure- activity relationship (QSAR).

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.69

How to cite this article: Aime A, Bagga H, Chaudhari G, Vyas U. Novel Approaches and Emerging Trends in Hydrotropic Solubilization Technology. International Journal of Drug Delivery Technology. 2024;14(3):1736-1744.

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