International Journal of Drug Delivery Technology
Volume 14, Issue 3

Optimizing Transdermal Patch Design: A Quality by Design Approach for Dysmenorrhea Relief

Sanjay Kumar1, Anirudh Singh Deora2*, Narahari KV3, Tanveer Shaikh4

1Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Etawah, Uttar Pradesh, India.

2Bhupal Nobles’in Institute of Pharmaceutical Sciences, Bhupal Nobles’ University, Udaipur, Rajasthan, India.

3KLE College of Pharmacy (Under KAHER Deemed to be a University) Bengaluru, Karnataka, India.

4Raosaheb Patil Danve College of Pharmacy, Badnapur, Maharashtra, India.

Received: 08th March, 2024; Revised: 26th May, 2024; Accepted: 02nd August, 2024; Available Online: 25th September, 2024

ABSTRACT

This study explores the potential of transdermal patches as a systemic delivery system for donepezil (DPZ), aiming to circumvent hepatic first-pass metabolism and mitigate oral administration-associated side effects. DPZ, known for its poor solubility and adverse effects, is formulated into transdermal patches using a matrix-type approach with PVP K30 and HPMC K100 polymers alongside dimethyl sulfoxide as a plasticizer. Through solvent casting on a mercury surface, the patches are prepared and assessed for physical properties and drug-excipient interactions using FTIR analysis. The results demonstrate satisfactory physical characteristics, including appearance, weight variation, and tensile strength. Notably, formulations containing HPMC K100 (400 mg) and PVP K30 (300 mg) exhibit enhanced DPZ discharge, signifying their potential as an effective drug delivery system for mitigating DPZ-associated side effects.

Keywords: Donepezil, Delivery, Patch, Permeation, Discharge.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.07

How to cite this article: Kumar S, Deora AS, Narahari KV, Shaikh T. Optimizing Transdermal Patch Design: A Quality by Design Approach for Dysmenorrhea Relief. International Journal of Drug Delivery Technology. 2024;14(3):1299-1305.

REFERENCES

  1. Ahad HA, Ishaq BM, Shaik M, Bandagisa F. Designing and characterizing of tramadol hydrochloride transdermal patches prepared with Ficus carica fruit mucilage and Pakistan Journal of Pharmaceutical Sciences. 2016;29(3).
  2. Jyothika LSK, Ahad HA, Haranath C, Kousar S, pal Gowd HD, Sadiya Lakunde Sathish Kumar Jyothika, Hindustan Abdul Ahad, Chinthaginjala Haranath, Shaik Kousar, Hothur Dharani pal Gowd, Sampathikota Halima Sadiya. Research Journal of Pharmaceutical Dosage Form and Technology. 2022:157-62.
  3. Jyothika LSK, Ahad HA, Haranath C, Kousar S, Sadiya SH. Types of transdermal drug delivery systems: a literature report of the past decade. 2022.
  4. Swetha T, Ahad HA, Reddy KK, Sekhar A, Sivaji S, Kumar B. Formulation and in-vitro permeation studies of Ketoprofen-Ficus reticulata fruit mucilage transdermal patches. Der Pharmacia Lettre. 2010;2(6):190-9.
  5. Ahad HA, Kumar CS, Ravindra B, Sasidhar C, Ramakrishna G, Venkatnath L, et Characterization and permeation studies of Diltiazem hydrochloride-ficus reticuleta fruit mucilage Transdermal patches. Int J Pharm Sci Rev Res. 2010;1(2):32-7.
  6. Thakur N, Goswami M, Deka Dey A, Kaur B, Sharma C, Kumar
  7. Fabrication and Synthesis of Thiococlchicoside Loaded Matrix Type Transdermal Patch. Pharmaceutical Nanotechnology. 2024;12(2):143-54.
  8. Devhare LD and Gokhale Antioxidant and Antiulcer Property of Different Solvent Extracts of Cassia Tora Linn. Research Journal of Pharmacy and Technology. 2022;15(3);1109-1113.
  9. Tiwari R, Mishra J, Devhare LD and Tiwari An updated review on recent developments and applications of fish collagen. Pharma Times. 2023;55(6):28-36.
  10. Aishwarya R, Ahad HA, Varsha S, Ranjitha Navigating the Global Landscape: A Comprehensive Review of Bower and Sulez’s Strategic Insights in the Pharmaceutical Industry. Research Journal of Pharmaceutical Dosage Forms and Technology. 2024;16(1):51-4.
  11. Tyeb S, Verma V, Kumar N. Polysaccharide based transdermal patches for chronic wound healing: Recent advances and clinical perspective. Carbohydrate Polymers. 2023:121038.
  12. Sahani P, Srilatha K, Ahad HA, Sah SK, Dkhar B, Prajapati From Concept to Assessment: Creating an Oral In-Situ Gelling System with Sucralfate. KEPES. 2023;21(3):555-67.
  13. Adimulapu AK, Devhare LD, Anasuya Patil A, Chachda NO,
  14. Dharmamoorthy. Design and Development of Novel Mini Tablet Cap Technology for the Treatment of Cardiovascular Diseases. International Journal of Drug Delivery Technology. 2023;13(3):801-806
  15. Chawla A, Devhare LD, Dharmamoorthy G, Ritika, Tyagi S. Synthesis and In-vivo Anticancer Evaluation of N-(4-oxo-2- (4-((5-aryl-1,3,4 thiadiazole-2yl) amino) Phenyl thiazolidine-3-yl) Benzamide derivative. International Journal of Pharmaceutical Quality Assurance. 2023;14(3):470-474.
  16. Gnana RPM, Devhare LD, Dharmamoorthy G, Khairnar MV, Prasidha R. Synthesis, Characterisation, Molecular Docking Studies and Biological Evaluation of Novel Benzothiazole Derivatives as EGFR Inhibitors for Anti-breast Cancer Agents. International Journal of Pharmaceutical Quality Assurance. 2023;14(3):475-480..
  17. Raghu U, Ahad HA, Satish P, Siddeshwara S, Dhanalakshmi A, Tejeshwini H. A quick reference to plant gums and mucilages used as a tablet International Journal of Pharma Sciences and Research. 2018;9(12):207-10.
  18. Shriram BK, Devhare LD, Mehrotra A, Deokar SS, Singh SP. Formulation and Evaluation of Mosquito Repellent International Journal of Drug Delivery Technology. 2023;13(4):1283-1286.
  19. Choudhary RK, Beeraka S, Sarkar BK, Dharmamoorthy G, Devhare L. Optimizing Verapamil Hydrochloride In-situ Delivery: A Strategic Formulation Approach using Box- Behnken Design for Enhanced Performance and Comprehensive Evaluation of Formulation Parameters. International Journal of Drug Delivery Technology. 2024;14(1):61-70..
  20. Pandey A, Gupta S. Evaluation of Formulated Transdermal Patches. Journal of Population Therapeutics and Clinical Pharmacology. 2023;30(16):793-8.
  21. Yilmaz EG, Ece E, Erdem Ö, Eş I, Inci A sustainable solution to skin diseases: ecofriendly transdermal patches. Pharmaceutics. 2023;15(2):579.
  22. Sonule M, Devhare LD, Babu MN, Gunjal SD, Varalaxmi S. Microemulgel-based Hydrogel of Diclofenac Sodium using Lipidium sativum as a Gelling Agent. International Journal of Drug Delivery Technology. 2023;13(4):1235-1239.
  23. Anusha G, Ahad H, Haranath C, Suryaprakash R, Kalpana K. A technical view on transporters-the drug pharmacokinetics dictators. MOJ Bioequiv Availab. 2019;9:47-52.
  24. Jwalapuram R, Ahad HA, Haranath C, Thadipatri R, Varshitha C, Kumar A desktop reference to the solubility enhancement of drugs with the aid of surfactants.(2020). Int J Life Sci Pharma Res.11(5):P11-6.
  25. Kumar KK, Kiran V, Choudhary RK, Devhare LD, Gunjal SD. Design Development and Characterization of Nicardipine Solid Lipid Nano-Particulars. International Journal of Drug Delivery 2024;14(1):71-78.
  26. Priya MGR, Prasanth LML, Devhare LD, Yazdan SK, Gunjal S. Synthesis, DNA Binding, Molecular Docking and Anticancer Studies of Copper (II), Nickel (II), and Zinc (II) Complexes of Primaquine-based Ligand. International Journal of Pharmaceutical Quality Assurance. 2024;15(1):69-75.
  27. Uplanchiwar VP, Raut SY, Devhare LD, et Pharmacological Assessment of Antiulcer Activity of Gloriosa Superba Linn Tubers In Experimentally Induced Gastric Ulcers. Journal of Medical Pharmaceutical and Allied Science. 2021;10(3);2852- 2856.
  28. Babu GN, Muthukaruppan M, Ahad Impact of Azadirachta indica Fruit Mucilage on particle size and swelling index in Central Composite Designed Acyclovir mucoadhesive microspheres. Baghdad Science Journal. 2023;20(2):04-25.