International Journal of Drug Delivery Technology
Volume 14, Issue 3

Nanosponges as a Drug Delivery System: Methods, Characteristics and Applications

Madhuri Mahesh Desai1*, Sujata Abhay Jadhav2, Akshada Amit Koparde3

1Department of Pharmaceutics, Krishna Vishwa Vidyapeeth, Krishna Institute of Pharmacy, Malkapur, Karad, Maharashtra, India.

2Department of Pharmacology, Krishna Vishwa Vidyapeeth, Krishna Institute of Medical Sciences, Malkapur, Karad, Maharashtra, India.

3Department of Pharmaceutical Chemistry, Krishna Vishwa Vidyapeeth, Krishna Institute of Pharmacy, Malkapur, Karad, Maharashtra, India.

Received: 20th December, 2023; Revised: 16th March, 2024; Accepted: 28th June, 2024; Available Online: 25th September, 2024 

ABSTRACT

Nanosponges, which are crosslinked polymer nanometers in sized used for drug transport, have a unique three-dimensional appearance. Their versatility lies in their ability to accommodate drugs of various sizes. The research approach, polymer type, and drug content determine the diversity of nanosponges. Nanosponges excel as delivery systems due to their capacity for controlled and targeted drug release. They offer the flexibility to regulate the duration of drug action and residence time. Their biodegradable composition ensures low toxicity and safe usage. Available voids, along with the size of the test molecule, play a crucial role in the efficiency of encapsulation. Nanosponges exhibit numerous applications such as cancer treatment, transportation of enzymes and biocatalysts, oxygen, modification of drug solubility, and immobilization of enzymes. This study emphasizes the preparation method, characterization, influencing factors, drug loading, recent advancements, and patents in the field of nanosponges.

Keywords: Controlled release, Crosslinked polymer, Nanosponge, Novel drug delivery, Targeted drug delivery. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.72

How to cite this article: Desai MM, Jadhav SA, Koparde AA. Nanosponges as a Drug Delivery System: Methods, Characteristics and Applications. International Journal of Drug Delivery Technology. 2024;14(3):1758-1764.

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