International Journal of Drug Delivery Technology
Volume 14, Issue 3

A Bird Eye View on In-situ Ophthalmic Gel: Challenges and Opportunities

Raghwendra R Waghmode1*, Dipak P Mali1, Pratibha Salve2, Shivsharan B Dhadde1

1Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India.

2Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India. 

Received: 20th January, 2024; Revised: 27th February, 2024; Accepted: 18th July, 2024; Available Online: 25th September, 2024 

ABSTRACT

Ophthalmic in-situ gel is an advanced formulation that converts from liquid to gel upon contact with the eye, providing SR of a drug. Precise examination is crucial because of the delicate nature of ocular drug administration. Traditional methods are inefficient, leading to the rapid elimination of drugs. This article explores polymers utilized in ophthalmic delivery of drugs, detailing their applications in addition to limitations. In-situ gelling mechanisms convert liquid preparations toward gels beneath specific conditions, enhancing the delivery of the drug upon contact with the eye. Various mechanisms like temperature, pH, and ion-induced gelation are employed based on drug characteristics and desired properties. Understanding these mechanisms allows for the design of ophthalmic gels that progress drug bioavailability and patient compliance. These polymers also aid in prodrug investigation as well as enhancing ophthalmic penetration. Overall, in-situ ocular gels offer a hopeful approach to incapacitating challenges in the ophthalmic delivery of drugs, providing efficient and versatile drug administration with prolonged retention and enhanced bioavailability.

Keywords: In-situ gel, Ophthalmic, Ophthalmic delivery of drug system, Bioavailability, Polymers, Application. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.77

How to cite this article: Waghmode RR, Mali DP, Salve P, Dhadde SB. A Bird Eye View on In-situ Ophthalmic Gel: Challenges and Opportunities. International Journal of Drug Delivery Technology. 2024;14(3):1801-1810.

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