International Journal of Drug Delivery Technology
Volume 14, Issue 3

Creation and Expansion of Bioadhesive Transdermal Gel of Levobupivacaine Loaded Nanoparticles for Enhancement of Anesthetic Effect

Ram Kumar Choudhary1, Anasuya Patil2*, Ramesh Abhimanyu Gadekar3, G Dharmamoorthy4

1Government Pharmacy Institute, Agam Kuan, Gulzarbagh, Patna, Bihar, India.

2Department of Pharmaceutics, KLE College of Pharmacy, II Block Rajajinagar, Bengaluru, Karnataka, India.

3KJ Educational Institute’s Trinity College of Pharmacy, Pisoli, Pune, Maharashtra, India.

4Department of Pharmaceutical Analysis, MB School of Pharmaceutical Sciences (Erstwhile Sree Vidyanikethan College of Pharmacy), Mohan Babu University, Rangampeta, Tirupati, Andhra Pradesh

Received: 16th March, 2024; Revised: 23rd May, 2024; Accepted: 02nd August, 2024; Available Online: 25th September, 2024

ABSTRACT

The present research work aimed to prepare a bioadhesive gel containing Levobupivacaine-loaded nanoparticles (NPs) to improve local anesthesia as transdermal patches were patient-friendly and easy to therapy. This study focuses on developing a The NPs were created using the ionotropic gelation method and assessed for particle charge, vesicle size and its distribution, and surface morphology. The improved NPs were incorporated into a gel and evaluated for their physicochemical assets. Among the NPs, NP4 was identified as the best based on its physicochemical properties. The NG-6 bioadhesive gel formulation stood out as the top gel among those tested. The NG-6 gel exhibited superior skin permeation ended 14 hours compared to other NPs. This bioadhesive transdermal gel with Levobupivacaine nanoparticles offers a promising approach to enhancing anesthetic effects.

Keywords: Bioadhesion, Gel, Levobupivacaine, Local anesthesia, nanoparticles, permeation.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.08

How to cite this article: Choudhary RK, Patil A, Gadekar RA, Dharmamoorthy G. Creation and Expansion of Bioadhesive Transdermal Gel of Levobupivacaine Loaded Nanoparticles for Enhancement of Anesthetic Effect. International Journal of Drug Delivery Technology. 2024;14(3):1306-1311.

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