International Journal of Drug Delivery Technology
Volume 14, Issue 3

Lipids Selection and Methods of Nanostructured Lipid Carrier for Topical Use

Rahman F1, Hendradi E2,3*, Purwanti T2,3

1Study Program of Pharmacy, Faculty of Health Science, Universitas Ibrahimy, Situbondo, Indonesia

2Departement of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

3Nanotechnology and Drug Delivery System Research Group, Faculty of Pharmacy, Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia 

Received: 24th February, 2024; Revised: 28th March, 2024; Accepted: 18th August, 2024; Available Online: 25th September, 2024 

ABSTRACT

Background: The utilization of nanoparticle systems presents a promising means for enhancing the efficacy of specific therapeutic interventions, particularly in topical applications. One of the nanoparticle systems that possesses several advantages is the nanostructured lipid carrier (NLC). It is comprised of solid and liquid lipids that form a lipid matrix with the addition of a surfactant. The utilization of lipids in NLC could impact various physical characteristics and drug release.

Objective: This study aims to ascertain the considerations involved in selecting solid and liquid lipids.

Method: The research approach to be undertaken is a systematic literature review, which refers to an investigation conducted through the process of identifying, evaluating, and interpreting all pertinent findings related to a study, topic, or phenomenon associated with NLC.

Results: the obtained results reveal that various NLC-related articles indicate that polymorphism, the solubility of active compounds, and the ratio of solid and liquid lipids may exert a significant influence on the physical characteristics and release of active compounds.

Conclusion: Consideration of the choice between solid and liquid lipids can be made to optimize topical therapeutic efficacy.

Keywords: Nanostructured lipid carrier, Liquid lipid, Solid lipid.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.87

How to cite this article: Rahman F, Hendradi E, Purwanti T. Lipids Selection and Methods of Nanostructured Lipid Carrier for Topical Use. International Journal of Drug Delivery Technology. 2024;14(3):1880-1889.

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