International Journal of Drug Delivery Technology
Volume 14, Issue 4

Formulation and Evaluation of Docetaxel Floating Microspheres

Arigela B1*, Talaparthi YD2, Chanumolu K2, Baratam A3

1Department of Pharmaceutics and Biotechnology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India

2KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India

3Department of Pharmaceutical Chemistry, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India 

Received: 31st Mar 2023; Revised: 27th Oct, 2024; Accepted: 5th Nov, 2024; Available Online: 25th Dec, 2024

ABSTRACT

This study sought to create floating microspheres containing Docetaxel, a cutting-edge anti-mitotic chemotherapeutic medication frequently used in the treatment of breast, ovarian, and non-small cell lung malignancies. The experimental results demonstrated that FT-IR evaluation exhibited no significant peak shifts, suggesting that the drug within the microspheres is stable in the short term. Biocompatible polymers, that include chitosan and albumin, were incorporated for the development of microspheres, both of which generated a great deal of drug entrapment and sufficient yield. All formulations have acceptable flow characteristics to allow for simple capsule loading. Furthermore, raising its polymer concentration resulted in an enormous decrease in cumulative drug release percentage. The formulations D7 is best fitted in various kinetic models

Key Words : Docetaxel, FT-IR, Microspheres, Bioavailability, Anti-mitotic, Chitosan, Albumin, Gelatin.

How to cite this article: Arigela B, Talaparthi YD, Chanumolu K, Baratam A. Formulation and Evaluation of Docetaxel Floating Microspheres. International Journal of Drug Delivery Technology. 2024;14(4):2048-53.doi 10.25258/ijddt.14.4.15

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