International Journal of Drug Delivery Technology
Volume 14, Issue 4

Polyherbal Formulation Development for Parkinson's Disease: Comprehensive Quality Control and Toxicological Evaluation

Gaurav Sharma1,2, Tejpal Yadav3, Sanjeev Sharma2, Vikram Kumar3*

1Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, Rajasthan, India

2National Institute of Ayurveda- Deemed to be University, Jaipur, Rajasthan, India.

3Amity Institute of Pharmacy, Amity University Rajasthan, Jaipur, Rajasthan, India 

Received: 17th Jul, 2024; Revised: 28th Sep, 2024; Accepted: 12th Oct, 2024; Available Online: 25th Dec, 2024

ABSTRACT

Background and objectives: In this study, extracts from eight herbal medicines Withania somnifera, Nardostachys jatamansi, Convolvulus pluricaulis, Mucuna pruriens, Centella asiatica, Bacopa monnieri, Tinospora cordifolia, and Ginkgo biloba were combined to create a potential medication. Methods: Quality Control study had been done according guideline or procedure drafted by CCRAS, Ministry of AYUSH, Govt. of India, Oral Acute and Repeated Dose 28-day Toxicity Study had been done according to OECD 423 and 407 guidelines. Results: The polyherbal formulation's physiochemical characteristics, phytochemical content, safety profile, and possible impacts on physiological parameters were all carefully assessed. The formulation was establish to be safe at a single administration dose of 2000 mg/kg and safe at repeated doses up to 1000 mg/kg over the course of 28 days. Conclusion: This study highlights the polyherbal formulation's potential for therapeutic application in the cure of Parkinson's disease by offering insightful information on its toxicological properties and quality control.

Keyword: Polyherbal formulation, HPTLC, Phytochemical, Physiochemical, toxicity study.

How to cite this article: Gaurav Sharma, Tejpal Yadav, Sanjeev Sharma, Vikram Kumar. Polyherbal Formulation Development for Parkinson's Disease: Comprehensive Quality Control and Toxicological Evaluation International Journal of Drug Delivery Technology. 2024;14(4):2073-80. doi: 10.25258/ijddt.14.4.19

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