International Journal of Drug Delivery Technology
Volume 14, Issue 4

Formulation and Evaluation of Cefixime Pediatric Medicated Lollipops

Vadivel SA1*, Sibichanduru E2, Saravanan S2, Karthik S2

1Department of Pharmaceutics, Surya school of Pharmacy, Surya group of institutions, Villupuram. Tamil Nadu, India

2Department of Pharmaceutics, Smt Gandhimathi College of Pharmacy, Thiruvannamalai, Tamil Nadu, India 

Received: 11th Aug, 2024; Revised: 26th Sep, 2024; Accepted: 25th Nov, 2024; Available Online: 25th Dec, 2024 

ABSTRACT

The study explores the formulation and evaluation of Cefixime medicated lollipops as a novel solution for paediatric oral drug delivery. The developed lollipops demonstrated desirable physical and pharmaceutical attributes, including consistent drug content, optimal hardness, and adherence to weight variation standards. Fourier-transform infrared spectroscopy confirmed the absence of significant drug-excipient interactions, ensuring formulation stability. Among the tested formulations, F2 exhibited the most promising results, achieving 100.05% cumulative drug release within 15 minutes during In vitro dissolution studies. Stability assessments over three months under accelerated conditions confirmed the lollipops' physical and chemical integrity, with drug content remaining within acceptable limits.This innovative dosage form addresses common challenges in pediatric drug administration by enhancing palatability, simplifying administration, and improving patient compliance. Additionally, the reduced dosing frequency associated with the formulation offers practical advantages for paediatric care. These findings position Cefixime medicated lollipops as a patient-friendly and efficient alternative to conventional paediatric dosage forms. It is recommended that further clinical studies be conducted to determine their effectiveness and safety in real-world paediatric settings.

Keywords: Cefixime, Medicated lollipops, Pediatric drug delivery, In vitro dissolution, Stability studies

How to cite this article: Vadivel SA, Sibichanduru E, Saravanan S, Karthik S. Formulation and Evaluation of Cefixime Pediatric Medicated Lollipops. International Journal of Drug Delivery Technology. 2024;14(4):2102-07.

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