International Journal of Drug Delivery Technology
Volume 15, Issue 3

Preparation and Characterization of Quercetin Phytosome

S D Pande*, S C Dhawale

School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded-431606, India

Received: 15th Jul, 2025; Revised: 29th Aug, 2025; Accepted: 7th Sep, 2025; Available Online: 25th Sep, 2025

ABSTRACT

The goal of this work is to improve quercetin's solubility and bioavailability by creating and characterizing quercetin phytosomes using the solvent evaporation technique. After obtaining phospholipids from ghee leftovers a quercetin-phosphatidylcholine complex was synthesized and its physicochemical characteristics were assessed. Analytical tools such as Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (IR), X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Transmission Electron Microscopy (TEM) were used to conduct the characterization. Quercetin and phosphatidylcholine have formed a stable combination, as shown by DSC and IR studies. XRD, on the other hand, showed a change to a less crystalline state, suggesting improved solubility. SEM and TEM images showed uniform, nanoscale spherical particles, supporting the successful encapsulation of quercetin. Thus, the 1:2 ratio is identified as the optimal formulation for maximizing practical yield, underscoring the importance of phospholipid concentration in achieving higher efficiency. The results indicate that the phytosome formulation enhances the stability, solubility, and bioavailability of quercetin, providing a promising strategy for its therapeutic applications

Keywords: Quercetin phytosome, phosphatidylcholine, solvent evaporation, drug delivery, bioavailability, characterization, nanoparticles, solubility enhancement.

How to cite this article: S D Pande, S C Dhawale. Preparation and Characterization of Quercetin Phytosome. International Journal of Drug Delivery Technology. 2025;15(3):941-46. doi: 10.25258/ijddt.15.3.5

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