Oxidative stress and inflammatory harm to heart tissue are main drivers of myocardial infarction (MI), which is a significant comprehensive health concern. Natural phytochemicals such as curcumin and ellagic acid have been found in preclinical studies to offer possible cardioprotective benefits. The purpose of this study was to compare individual and combination cardioprotective effects of curcumin and ellagic acid in isoproterenol (ISO)-induced myocardial damage in Wistar rats. This in-vivo investigation used 54 healthy Wistar rats. Acute oral toxicity was assessed using OECD Guideline 423. To assess efficacy, 42 rats were randomized into seven groups: normal control, disease control (ISO only), standard medicine (Gemfibrozil), and treatment groups receiving Curcumin (300-400 mg/kg), Ellagic Acid (60-80 mg/kg), or a combination. ISO (85 mg/kg) was administered subcutaneously on days 29 and 30 to cause myocardial damage. The cardioprotective effects were evaluated using serum biomarkers (CPK, Troponin-I), oxidative stress indicators (LPO, GSH, CAT, SOD), and histological investigation of heart tissue. ISO treatment increased serum cardiac biomarkers and oxidative stress markers while causing histological heart damage. When compared to disease control group, management by curcumin and ellagic acid, specifically together, dramatically improved heart histoarchitecture and restored biochemical markers (p < 0.05). The study establishes that ellagic acid and curcumin have effective cardioprotective assistances against rats' hearts damaged by ISO. Their combination demonstrated enhanced efficacy, most likely due to synergistic antioxidant characteristics, highlighting their possible as complimentary medicines in cardiovascular therapy.
Keywords: Curcumin, Ellagic Acid, Cardioprotection, Isoproterenol, Myocardial Infarction.
How to cite this article: Patwekar V, Rajurkar V. In-Vivo Evaluation of Cardioprotective Effects of Curcumin and Ellagic Acid in Isoproterenol-Induced Myocardial Injury in Rats. Int J Drug Deliv Technol. 2025;15(4): 1555-1569, DOI: 10.25258/ijddt.15.4.11