Boerhavia diffusa, commonly known as Punarnava, is a medicinal herb belonging to the Rubiaceae family, traditionally used in Ayurveda for its diuretic, hepatoprotective, anti-inflammatory, and antimicrobial properties. This study investigates the extraction, phytochemical screening, and development of nanofiber formulations using Boerhavia diffusa root and leaf extracts, followed by an evaluation of their antimicrobial activities. Ethanol extracts exhibited the highest yield (5.9% for roots and 5.2% for leaves), while chloroform extracts demonstrated the lowest yield (1.26% in leaves). Phytochemical analysis confirmed the presence of bioactive compounds, including carbohydrates, proteins, steroids, terpenoids, glycosides, saponins, flavonoids, alkaloids, and tannins. Antimicrobial assessments indicated that ethanol extracts exhibited the most potent inhibition against Staphylococcus aureus and Candida albicans, while aqueous extracts were most effective against Aspergillus niger. Nanofiber-based drug delivery systems were employed to enhance the bioavailability and targeted delivery of these bioactive compounds. The porous structure and high surface area of the nanofibers provided sustained drug release, demonstrating their potential in antimicrobial applications and wound healing. This study supports the further development of Boerhavia diffusa-based nanofiber systems as innovative therapeutic solutions in contemporary medicine.
Keywords: Boerhavia diffusa, nanofiber, antimicrobial, wound healing.
How to cite this article: Borkar S; Dhakad PK; Yadav HS, Boerhavia diffusa-Loaded Nanofibers: Phytochemical Insights and Antimicrobial Potential. Int J Drug Deliv Technol. 2025;15(4): 1771-1775, DOI: 10.25258/ijddt.15.4.29