Formulation and Evaluation of Xanthan Gum-Based Naproxen Matrix Tablets for Controlled Drug Release

Rakesh S. Dhole¹*, Venkata Ramana Singamaneni², Gurmeet Singh Chhabra³, Poonam P. Taru⁴, Sandeep S. Pathare ⁵_, Yogyata S. Pathare⁶, Bundurani L G P Ram⁷, Sachin S. Sakat⁸

¹Department of Pharmaceutical Chemistry, KVPS’s Maharani Ahilyabai Holkar College of Pharmacy, Shirpur, Dhule-425405 M.S. India.
²Cambrex Charles City, Iowa, USA.
³Department of Pharmaceutical Chemistry, Indore institute of pharmacy, Pithampur road, Indore-453331 (M.P) INDIA.
⁴Department of Pharmacognosy, School of Pharmacy, Vishwakarma University, Kondhwa Pune- 411048 M.S. India.
⁵Department of Pharmaceutical Chemistry, Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy, Erandwane, Pune- 411038, M.S., India.
⁶Department of Pharmaceutics, STES's Sinhgad College of Pharmacy, Vadgaon, Bk. Pune- 411041, M.S. India.
⁷Department of Pharmacognosy, SGMSPM's Dnyanvilas College of Pharmacy, Dudulgaon, Pune- 412105 M.S. India.
⁸Department of Pharmacology, Shri Ganpati Institute of Pharmaceutical Sciences and Research, Tembhurni, Solapur- 413211, India.

Received: 16^th Aug, 2025; Revised: 14^th Sep 2025; Accepted: 14^th Nov, 2025; Available Online: 30^th Nov, 2025

ABSTRACT

Current research focuses on the formulation and assessment of the skillful announcement medium tablet of Neproxon by means of Xanthan secretion as a natural hydrophilic polymer. Matrix pills were formulated using the direct compression technique with separate concentrations of zanthan gum (100–300 mg), and was evaluated for physical chemical parameters including rigidity, magnitude, weight variation, thickness and pharmaceutical materials, including all Indian pharmacopial borders. The FTIR and DSC confirmed pharmaceutical compatibility-polymer without any significant talks. The drug material uniformity ranged from 93.2% to 101.23%, ensuring homogeneous drug delivery. In vitro pharmacological announcement educations remained conducted in 0.1 Normal HCL (Ph1 1.2) for 2 times, succeeded through Phosphate bumper (pH 6.8) for 10H. Formulation F -3 performed 71% cumulative release in 12 hours, equivalent to marketing formulation (73%). Kinetic Modeling Reveled That The medication announcement adhered to a nothing-instruction kinetics model Kinetics (R² = 0.9587 for sgf, 0.9691 for mf) with strong linearity, Whilee Korsmeyer-Peppas Analysis (n = 0.7321–0.8431) indicated a non-budgetian (anomalous) transport mechanism, governed by both polymer Relaxation/Erosion and DIFFUSION. Quick constancy educations (40 ° 2 ° C, 75, 5% Rh, 60 days) did not make slightly important changes to hardness, horrific, pharmaceutical material or release profiles, ensuring good stability. Finally, Xanthan gum proved to be an effective, safe and affordable polymer to develop controlled-controlled-neproxon pills, achieve prolonged pharmaceutical release, enhanced bioavailability, and improved patient adherence.

Keywords: Naproxen, Xanthan gum, Skillful announcement, Medium drugs, In-vitro drug announcement, Stability education, Release kinetics, Direct Compression.

How to cite this article: Dhole RS; Singamaneni VR; Chhabra GS; Taru PP; Pathare SS; Pathare YS; Ram BLGPR; Sakat SS, Formulation and Evaluation of Xanthan Gum-Based Naproxen Matrix Tablets for Controlled Drug Release. Int J Drug Deliv Technol. 2025;15(4): 1794-1804, DOI: 10.25258/ijddt.15.4.32