Hematopoietic stem cells (HSCs) play a central role in the regeneration of the hematopoietic system and maintaining blood cell homeostasis. The physiologically hypoxic bone marrow environment is known to support the quiescence and viability of HSCs. 1 Hypoxic preconditioning, which involves controlled exposure to hypoxia before transplantation or therapeutic use, has been shown to enhance the viability and homing effectiveness of HSCs by modulating cytokine and chemokine expression. 2,3 Molecules such as stromal-derived factor-1 (SDF-1), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF), and their receptors such as CXCR4 show increased expression after hypoxic preconditioning, which supports migration and engraftment. 4,5 This study is a systematic review aimed at identifying and analyzing changes in cytokine and chemokine expression in HSCs following hypoxic preconditioning. The literature search was conducted using the PRISMA protocol through the PubMed, Scopus, and ScienceDirect databases. Eligible studies included in vitro, in vivo, and ex vivo experiments. The results showed that Hypoxic preconditioning consistently affects the expression of immune and regenerative regulatory molecules, strengthening its potential for optimizing HSC-based therapies.. ..
Keywords: hematopoietic stem cells, hypoxia, cytokines, chemokines, regenerative therapy, SDGs
How to cite this article: Ardhani GAW; Ramadayanti SL; Patera AN; Cytokine and Chemokine Profiling Hematopoietic Stem Cell Precondition Hypoxia. Int J Drug Deliv Technol. 2025;15(4): 1909-1913, DOI: 10.25258/ijddt.15.4.45