Vitex negundo Linn (family Verbenaceae), commonly known as Nirgundi, is a medicinal plant extensively used in traditional Ayurvedic systems for treating inflammatory and rheumatic disorders. This review combines recent scientific data on its pharmacological, biochemical, and clinical potential in the management of Rheumatoid Arthritis (RA). This plant has a wide variety of therapeutic effects such as anti-inflammatory, anti-oxidant, analgesic, and immunomodulatory effects mainly inhibited by COX, LOX, TNF-α, IL-1β and NF-κB signaling pathways. The therapeutic benefits are attributed to bioactive compounds such as casticin, negundoside and luteolin contributing to the multi-targeted therapeutic paradigm. The pre-clinical applicability is attractive and is associated with a clinically meaningful beneficial impact on joint inflammation, oxidative stress, and cytokine balance and safety confirmed with positive toxicology. The limitations are in clinical validation and standardization. The way forward would be to focus on multi-centric clinical studies and mechanistic studies using medical-omics approaches to better understand the favorable outcomes of V. negundo, including innovative formulations to optimize bioavailability and reproducibility. Overall, V. negundo Linn is defined as a multi-faceted complementary or adjunct treatment option for the management of RA, bridging traditional knowledge with contemporary pharmacology. ..
Keywords: Vitex negundo Linn, Rheumatoid Arthritis, Anti-inflammatory, Immunomodulatory, Phytochemicals, Clinical Validation.
How to cite this article: Bhivshet G, Banweer J.; Impact of Vitex Nigunda Linn on the treatment of Rheumatoid Arthritis. Int J Drug Deliv Technol. 2025;15(4): 1914-1928, DOI: 10.25258/ijddt.15.4.46