The formulation and optimzation of controlled release resinates beads of Eperisone HCl (EpHCl) allowed for once a day administration, which improved patient compliance and eliminated the danger of medication intolerance. EpHCl is a readily water-soluble substance with a short half-life. Next, the EpHCl-resin combination was covered with a layer of Kollicoat SR-30D . The EpHCl release rate from the microcapsules was optimized using a 24 factorial design, which included variables such as the concentration of Kollicoat SR 30D (X1), % coating (X2), rotation speed (X3), and the concentrations of plasticizer (PEG 400) (X4). As for the dependent variables, we chose coating extent (Y1) and medication release % at specific periods (Y2, Y3, and Y4). The optimization procedure was then carried out for X1, X2, X3, and X4. At 1495 rpm, X1, X2, and X3 levels are at 14.42%, 50.63%, and 9.94%, correspondingly, in the optimized EpHCl microcapsules. The opted EpHCl microcapsules placed inside capsules had a f2 value of 71.24, which means that the optimized formulation's dissolving profiles are similar to the targeted releasing model's. ..
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How to cite this article: Yadav RK, Singh C, Sharma V. Design, Development and Optimization of Controlled release Formulation for a freely BCS class I Eperisone HCl. Int J Drug Deliv Technol. 2025;15(4): 2009-2017, DOI: 10.25258/ijddt.15.4.54