Ion-exchange resin (IERs) are also reported to ensure enhanced safety of drugs, especially pediatric preparations and abuse-deterrent systems (ADS). These resins are being modeled to bind drug molecules, whereby the release can be controlled, the taste can be masked, and the adherence to the patients can be improved. Pediatricians have discovered that in the area where drug adherence is critical, IERs assist in mitigating dosage issues and drug palatability, a factor that has at least served to support medication compliance by at least 25%. In the meantime, IERs will serve as a discouragement to the abuse of drugs, as it will make it more difficult to abuse the drug. The dual advantage in achieving therapeutic effect and safety prioritizes the applicability of the IERs specifically in chronic pediatric care, including ADHD and asthma care, and addressing the rising issue of the abuse of opioids and stimulants. This study synthesizes the results of clinical interventions and regulatory publications (2019-2024) to assess the usefulness of IER-based regimes in enhancing pediatric adherence and preventing abuse. Findings indicate that compliance with safety has greatly improved, such as a 30% decrease in malignancy and a 25% decrease in compliance. These results demonstrate a promising role of IERs to enhance safety and compliance in drug delivery systems, with broad validity in the pharmaceutical design and in the health policy of the population.
Keywords: Ion-exchange resins (IERs), Pediatric formulations, Abuse-deterrent systems (ADS), Drug delivery safety, Patient adherence
How to cite this article: Kesarpu S, Patel R., Bridging Safety and Compliance: The Dual Role of Ion-Exchange Resins in Pediatrics and Abuse-Deterrent Drug Delivery. Int J Drug Deliv Technol. 2026;16(1): 148-159, DOI: 10.25258/ijddt.16.1.16