Chitosan–polyvinyl alcohol (PVA) film dressings have been widely recognized for their biocompatibility, biodegradability, and favorable physicochemical properties, making them suitable candidates for wound management. The integration of Aloe vera extract, known for its anti-inflammatory, antimicrobial, and pro-regenerative effects, is hypothesized to potentiate the therapeutic efficacy of such composite films. This study aimed to investigate the wound-healing potential of chitosan–PVA films incorporated with Aloe vera using a second-degree burn wound model in Wistar rats (Rattus norvegicus). Composite films were fabricated via solvent casting with varying ratios of chitosan, PVA, and Aloe vera. Wound healing was assessed over 14 days through quantitative measurement of wound contraction and qualitative macroscopic evaluation of tissue regeneration. Results revealed that films containing Aloe vera demonstrated significantly enhanced wound closure compared with both chitosan–PVA films without Aloe vera and the positive control. These findings highlight the synergistic interactions among chitosan, PVA, and Aloe vera, suggesting that these composite films may serve as a promising bioactive dressing for accelerated burn wound healing.
Keywords: composite film fabrication, chitosan, polyvinyl alcohol, Aloe vera, wound healing
How to cite this article: Zatalini DF, Sari R, Hendradi E, Biocomposite Films of Chitosan–PVA–Aloe vera for the Burns Management in Wistar Rats Model. Int J Drug Deliv Technol. 2026;16(1): 315-320. DOI: 10.25258/ijddt.16.1.34