Pomegranate peel is a promising source due to its rich content of biologically active compounds and proven medicinal properties. This study aimed to obtain extracts from pomegranate peels grown in Armenia using different technological methods and to perform a phytochemical analysis of the compounds responsible for the main biological activity in these extracts: flavonoids and organic acids. The raw material was standardized by determining the content of flavonoids, organic acids, and water content using appropriate methods. Liquid extracts from pomegranate peel were obtained through maceration for three days and ultrasonic extraction using 80% ethyl alcohol, with varying degrees of raw material grinding. The optimal extraction method, which ensures the maximum content of active substances, was ultrasonic extraction using 80% ethyl alcohol with a particle size of 0.5-1 mm of the raw materials. The results demonstrate that the extracts show high antioxidant properties in in vitro tests, comparable to those of ascorbic acid.
Keywords: pomegranate peel, flavonoids, organic acids, ultrasonic extraction, maceration, antioxidant activity
How to cite this article: Tonoyan I, Topchyan H, Mkhitaryan S, Zhamharyan A, Phytochemical Analysis and Determination of the Antioxidant Activity of Pomegranate (Punica Granatum) Peel Growing in Armenia. Int J Drug Deliv Technol. 2026;16(1): 361-366. DOI: 10.25258/ijddt.16.1.39