1Mohamed Sathak A.J. College of Pharmacy, Medavakkam High Road, Sholinganallur, Chennai, Tamil Nadu, India
2*JKKMMRF's Annai JKK Sampoorani Ammal College of Pharmacy, Komarapalyam, Namakkal, The Tamil Nadu Dr. MGR Medical University, Tamil Nadu, India
Received: 15th Sep, 2025; Revised: 15th Oct, 2025; Accepted: 16th Nov, 2025; Available Online: 1st December, 2025
The present study examines the hepatoprotective effects of the leaf extract (DME) of Dysoxylum malabaricum (Indian white cedar) and an isolated compound (IDM) of this plant on hepatoprotection against paracetamol-induced liver toxicity in albino Wistar rats. The acute oral toxicity was tested using ethanol-extracted leaf fractions which were separated using column chromatography. After the hepatotoxicity caused by paracetamol, rats were grouped and subjected to DME, IDM or hepatoprotective agent silymarin. Biochemical indicators, such as ALT, AST, ALP, bilirubin, and antioxidant enzymes (SOD, CAT, GPx), and histopathological examinations of liver tissue were used as protective measures. The results showed that at higher doses (500mg/kg DME and 50mg/kg IDM), both of the treatments enhanced the liver functioning markers, reconstituted the antioxidant levels of the enzymes, and lowered lipid peroxidation. It is worth noting that IDM exhibited a strong tissue regeneration and dose-effect in the histopathological analysis. Their protective effects were also enhanced by the improvement of lipid profiles and body weight. On the whole, the research confirms that D. malabaricum and IDM have important hepatoprotective potential, which proves their traditional application in ethnomedicine and promotes their future pharmaceutical exploitation as agents against liver diseases. These findings are supportive to the ongoing clinical studies, which would legitimize and apply these findings into therapeutic use.
Keywords: Dysoxylum malabaricum, hepatoprotection, paracetamol-induced hepatotoxicity, antioxidant enzymes, liver function markers, lipid profile, histopathology.
How to cite this article: Sangeetha PT, Venkatachalam T, Kalaiselvi P. Hepatoprotective Effects of Leaves of Dysoxylum Malabaricum an Endangered Medicinal Plant and Its Isolated Compound against Paracetamol Induced Hepatotoxicity in Rats. Int J Drug Deliv Technol. 2026;16(1): 649-658; DOI: 10.25258/ijddt.16.1.67
Source of support: Nil.
Conflict of interest: None