1,2,3,6,7Department of Reproductive Medicine, Chennai Fertility Centre and Research Institute, Chennai, Tamilnadu, India
4Department of Botany, Government Arts College, Coimbatore, Tamilnadu, India
5*Department of Biotechnology, Dr. N.G.P. Arts and Science College, Coimbatore, Tamilnadu, India (Corresponding Author)
Received: 18th Sep, 2025; Revised: 26th Oct, 2025; Accepted: 26th Nov, 2025; Available Online: 1st December, 2025
Male infertility is primarily diagnosed through semen analysis; however, this method provides only a limited understanding of the underlying causes. Various factors, including infections, systemic diseases, and environmental exposures, can alter semen composition hence semen analysis is alone to diagnose of male infertility and often leads to inconclusive results and delayed diagnoses. To address these limitations, current research is focused on identifying biomarkers in seminal plasma, which may enhance diagnostic accuracy. Seminal plasma is a crucial biological fluid containing key reproductive gland secretions essential for sperm motility and its overall function.
Aim: The present study aims to conduct a comparative analysis of biochemical markers in seminal plasma and serum among fertile and infertile men.
Methodology: This prospective study was carried out in the Department of Embryology, Chennai, India. A total of 76 male participants, categorized as either fertile or infertile, were assessed for serum and seminal plasma levels of biochemical markers. Glucose, urea, uric acid, copper, albumin, SGOT, SGPT, LDH, and total cholesterol were determined using spectrophotometric method. Statistical analysis revealed significant differences between the groups, highlighting the importance of biochemical factors in male fertility.
Result: No significant differences were observed in serum biochemical parameters. However, in seminal plasma, levels of lactate dehydrogenase (LDH), total cholesterol, aspartate aminotransferase (SGOT) were significantly different (p<0.01) between the groups.
Conclusion: These findings underscore the potential of seminal plasma biochemical profiling as a valuable diagnostic tool for evaluating male fertility. The role of trace elements and biochemical markers in sperm function is critical, offering essential insights into the diagnosis, management, and prevention of male infertility.
Keywords: Seminal Plasma; Blood serum; Biochemical Markers; Male infertility.
How to cite this article: Deepa O, Krishnavignesh L, Sridev S, Mahalakshmipriya A, Poongothai M, Thomas VM, Devakumar. Biochemical Markers In Seminal Plasma And Serum: A Comparative Assessment In Fertile And Infertile Men. Int J Drug Deliv Technol. 2026;16(1): 676-688; DOI: 10.25258/ijddt.16.1.70
Source of support: None
Conflict of interest: None