1Department of General Surgery, Meenakshi Medical College Hospital and Research Institute, Meenakshi Academy of Higher Education and Research
2Department of Cardiology, Meenakshi Medical College Hospital & Research Institute, Meenakshi Academy of Higher Education and Research
3Department of Cardiology, Meenakshi College of Allied Health Sciences & Meenakshi Medical College Hospital & Research Institute, Meenakshi Academy of Higher Education and Research
4Department of Pharmacology, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research
5Arulmigu Meenakshi College of Nursing, Meenakshi Academy of Higher Education and Research
6Meenakshi College of Physiotherapy, Meenakshi Academy of Higher Education and Research
Background: The presence of cardiac, renal and metabolic disorders among adults is often predetermined by a common risk factor and the presence of a common pathophysiology, as well as the ability to enhance each other. This three-fold, commonly known as cardiorenal-metabolic multimorbidity, causes a significant amount of hospitalization, polypharmacy and mortality. Although increased awareness is present, evidence on true overlap and its clinical consequences has not been well-estimated on a population level.
Objective: To evaluate the commonness of comorbid cardiac, renal, and metabolic disorders among adults and determine their predictive healthcare use and poor clinical outcomes.
Method: The study design was a cross-sectional study with the use of electronic health records of adult patients 18 years old in a large health system. Diagnostic codes, laboratory thresholds and medication profiles were used to find cardiac disease, chronic kidney disease and metabolic disorders (diabetes or obesity). Outcome measures were hospitalization rates, emergency visits and all-cause mortality.
Results: Out of 182,000 adults, 27% of them had a disease at least; 11% of them had complete cardiorenal-metabolic overlap. Patients who were multimorbid incurred much higher rates of hospitalization, extended medication burden and mortality rates one year post-discharge relative to those who had single conditions. The number of overlap disorders was proportional to risk.
Conclusion: There is a high rate of cardiorenal-metabolic multimorbidity, which is closely linked to poor outcomes. Long-term health and reduction of the risk should be based on early detection and combined methods of management.
Keywords: Cardiorenal metabolic multimorbidity, chronic kidney disease, heart failure, multisystem disease, population health
How to cite this article: Ganesan M, Aashish A, Rose S, Packirisamy S, Kalpana P, Rani S. The Overlap of Cardiac, Renal and Metabolic Conditions in Adults: Prevalence and Implications. Int J Drug Deliv Technol. 2026;16(10s): 191-195; DOI: 10.25258/ijddt.16.10s.28
Source of support: Nil.
Conflict of interest: None