Microballoons in Peptic Ulcer Therapy: A Gastroretentive Novel Approach

^1,2 R. Uma Prabha, ² Dr. Akilandeswari, ¹ Sahala K, ¹ Sai sravan P, ¹ Sakshi Korgaonkar, ¹ Sangeetha R, ¹ Tejashwini N, ¹ Varshitha A

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ABSTRACT

Peptic ulcer is a common gastrointestinal disorder characterized by lesions, inflammation, or irritation in the stomach or duodenal mucosa. The conventional therapy of peptic ulcers has many limitations including frequent dosing, decreased bioavailability, and multiple drug treatments that lead to patient non-compliance. Gastroretentive Drug Delivery Systems (GRDDS) represent an innovative approach to overcome these challenges by enhancing drug bioavailability and improving therapeutic outcomes. In particular, microballoons have demonstrated great potential in prolonging gastric retention, lowering the frequency of doses, and enhancing drug absorption. This review provides an overview of current peptic ulcer treatments, and the novel drug delivery methods, focusing on microballoons in treating peptic ulcers. It highlights properties of microballoons, its preparation, evaluation, advantages, and various antiulcer drug loading microballoons formulated in research.

KEYWORDS: Microballoons, Peptic ulcer, Gastro retentive drug delivery system, Floating drug delivery system, Extended drug release.

How to cite this article: Prabha RU, Akilandeswari, Sahala K, Sai sravan P, Korgaonkar S, Sangeetha R, Tejashwini N, Varshitha A. Microballoons in Peptic Ulcer Therapy: A Gastroretentive Novel Approach. Int J Drug Deliv Technol. 2026;16(10s): 323-332; DOI: 10.25258/ijddt.16.10s.44

Source of support: Nil.

Conflict of interest: None