1*Department of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, India. Email: ranaujjwal999@gmail.com
2Department of Pharmaceutical Chemistry, Pacific College of Pharmacy, PAHER, Udaipur, Rajasthan, India. Email: jadon_gunjan@yahoo.in
3Department of Pharmaceutical Chemistry, Pacific College of Pharmacy, PAHER, Udaipur, Rajasthan, India.
4Department of Pharmaceutical Chemistry, Pacific College of Pharmacy, PAHER, Udaipur, Rajasthan, India.
Insomnia is a common sleep disorder involving difficulty in falling or staying asleep, or not feeling rested after sleep. It affects a large portion of adults and can result from medical, psychological, or lifestyle factors. If untreated, it increases the risk of conditions such as depression, anxiety, heart disease, and reduced daily performance. When non-drug methods are ineffective, medications like benzodiazepines and non-benzodiazepine "Z-drugs" such as zolpidem are prescribed. Zolpidem tartrate acts quickly to induce sleep but has a short duration of action, often leading to incomplete sleep maintenance. To address this, Biphasic Drug Delivery Systems using Multiple Unit Pellet Systems (MUPS) have been developed, offering both rapid sleep induction and prolonged effect while minimizing side effects and the risk of dependence.
Keywords: Multiple Unit Pellet Systems (MUPS), Zolpidem tartrate, Biphasic Drug Delivery System, Formulation, Evaluation.
How to cite this article: Rana U, Jadon G, Kishor A, Choudhury PK. Formulation and Evaluation of Biphasic Drug Delivery System of Zolpidem Tartrate using MUPS. Int J Drug Deliv Technol. 2026;16(10s): 671-682; DOI: 10.25258/ijddt.16.10s.81
Source of support: Nil.
Conflict of interest: None