1Shri Shankaracharya Professional University, Bhilai
2Shri Shankaracharya College of Pharmaceutical Sciences, Junwani, Bhilai
Polymeric nanoparticles (PNs) are the first generation of lipid-based nanocarriers that are formulated from lipids, which are solid in the body temperature and stabilized by emulsifiers. PNs are composed of well-tolerated and biodegradable solid lipids such as mono-, di-, and triglycerides, fatty acids, waxes, and steroids, as well as lipophilic and hydrophilic emulsifying agents. This composition of biocompatible molecules makes PNs one of the most successful options for the administration of drugs with different routes of administration. PNs have been sought as a means to improve the solubility and bioavailability of many drugs, both hydrophilic and lipophilic, especially drugs belonging to class two (high permeability and low solubility drugs) and four (low permeability and low solubility drugs) of the biopharmaceutical classification system (BCS). PNs provide several indirect ways to address resistance problems, such as achieving a sustained release profile of a drug, maintaining concentrations within its therapeutic range, and thus avoiding potential adverse effects.
Keywords: L-Leucine, Polymeric Nanoparticles, Colloidal carriers, Liver Disease, Sustained release
How to cite this article: Kumar P, Shrivastava S. Preparation and Evaluation of L-Leucine Loaded Polymeric Nanoparticles for the Management of Liver Disease. Int J Drug Deliv Technol. 2026;16(10s): 731-740; DOI: 10.25258/ijddt.16.10s.86.
Source of support: Nil
Conflict of interest: None