1Research Scholar, Department of Pharmacology, Samarth College of Pharmacy, Deulgaon Raja, Dist. Buldhana – 443204, Maharashtra, India. ORCID: 0009-0005-9195-8648
2Assistant Professor, Department of Pharmacology, Samarth College of Pharmacy, Deulgaon Raja, Dist. Buldhana – 443204, Maharashtra, India. ORCID: 0009-0005-5490-5168
3Head of the Department, Department of Pharmacology, Samarth College of Pharmacy, Deulgaon Raja, Dist. Buldhana – 443204, Maharashtra, India. ORCID: 0009-0001-8012-0736
4Principal, Samarth College of Pharmacy, Deulgaon Raja, Dist. Buldhana – 443204, Maharashtra, India. ORCID: 0000-0003-2163-2974
*Corresponding Author: Ghube D. D, Head of the Department, Department of Pharmacology, Samarth College of Pharmacy, Deulgaon Raja, Dist. Buldhana – 443204, Maharashtra, India
Wound healing is a complex, multistage physiological process involving hemostasis, inflammation, proliferation, and tissue remodeling, aimed at restoring structural and functional integrity of damaged skin. However, the effective management of acute and chronic wounds remains challenging due to persistent microbial infections, excessive inflammation, oxidative stress, and the emergence of antimicrobial resistance. In recent years, increasing attention has been directed toward plant-based therapeutics as safer and cost-effective alternatives to conventional treatments. Among these, polyherbal formulations have emerged as a promising strategy owing to their synergistic interactions, which enhance therapeutic efficacy while minimizing adverse effects. This review critically examines the role of polyherbal antimicrobial creams in wound healing, focusing on their phytochemical composition, pharmacological mechanisms, and therapeutic potential. Key medicinal plants such as Aloe vera, Allium sativum, Curcuma longa, Azadirachta indica, Carica papaya, Glycyrrhiza glabra, Ocimum sanctum, Melaleuca alternifolia, Sida acuta, and Moringa oleifera are discussed with respect to their bioactive constituents and reported activities, including antimicrobial, anti-inflammatory, antioxidant, and collagen-promoting effects. The review further highlights the significance of controlling wound microbiota, particularly pathogenic organisms such as Staphylococcus aureus and Pseudomonas aeruginosa, in accelerating the healing process. Collectively, polyherbal antimicrobial creams offer a multifaceted therapeutic approach by integrating infection control with enhanced tissue regeneration. Despite promising preclinical evidence, challenges related to standardization, formulation optimization, and clinical validation remain. Therefore, future research should emphasize well-designed experimental and clinical studies to establish the efficacy, safety, and reproducibility of these formulations for their successful translation into modern wound care systems.
Keywords: Polyherbal formulation; Wound healing; Antimicrobial activity; Phytochemicals; Herbal medicine; Topical drug delivery; Tissue regeneration
How to cite this article: Jaybhaye V.V, Alhat R. M, Ghube D. D, Tathe P. R, Polyherbal Antimicrobial Creams in Wound Management: A Critical Review of Phytochemistry and Pharmacological Evidence. Int J Drug Deliv Technol. 2026;16(11s): 1011-1021. DOI: 10.25258/ijddt.16.11s.100
Source of support: None
Conflict of interest: None