1PhD Research Scholar, JSS Dental College, Mysore
2Professor, Dept of Prosthodontics, JSS Dental College, Mysore
3Research Guide, Obstetrics and Gynaecology, TMM Hospital, Tiruvalla
4Professor, Cellular and Molecular Biology, CEMR laboratory, JSS Medical College
5Reader, Dept of Prosthodontics, JSS Dental College, Mysore
6Professor, Dept of Periodontology, JSS Dental College, Mysore
*Corresponding Author: Christina Amy Mathews, PhD Research Scholar, JSS Dental College, Mysore
Exosomes, nanoscale extracellular vesicles (EVs), are secreted by diverse cell types including mesenchymal stem cells, T lymphocytes, neurons, and mast cells. Saliva is among the body fluids that contain exosomes. Saliva is gaining prominence as a diagnostic biofluid due to its non-invasive and cost-effective collection. Salivary exosomes contribute significantly to maintaining oral homeostasis, modulating immune responses, and regulating the oral microbiome. Composed of proteins, lipids, RNA, and DNA, exosomes mediate intercellular communication and transport molecular cargo between cells. Due to their biological content and specific surface markers, salivary exosomes show strong potential in diagnostics, targeted drug delivery, immunomodulation, and tissue regeneration. This manuscript explores the structural components, biological functions, isolation techniques, and analytical methods associated with salivary exosomes, highlighting their role in oral and systemic health and their translational potential in clinical applications.
Keywords: Exosomes, Salivary Exosomes, Extracellular Vesicles, Molecular Transport
How to cite this article: Mathews CA, Gujjari AK, Mathews BS, Madhunapantula SV, Sowmya S, Gujjari SK. Saliva's Secret Weapon: Understanding the Multifaceted Role of Exosomes. Int J Drug Deliv Technol. 2026;16(11s): 107-109; DOI: 10.25258/ijddt.16.11s.12
Source of support: Nil.
Conflict of interest: Nil