1Associate Professor, Department of Pharmaceutics, Kamarajar College of Pharmacy, Cuddalore, Tamilnadu
2Principal, Kamarajar College of Pharmacy, Cuddalore, Tamilnadu
3HOD, Department of Pharmaceutics, Kamarajar College of Pharmacy, Cuddalore, Tamilnadu
4Students, Kamarajar College of Pharmacy, Cuddalore, Tamilnadu
Corresponding author: V.G. Akilandeswari, Department of Pharmaceutics, Kamarajar College of Pharmacy, The Tamil Nadu Dr. M.G.R. Medical University, Chidambaram, Cuddalore 608602, Tamilnadu, India. Email: santhasabarivg@gmail.com; Tel: +917904404057
Chronic wounds, especially amongst human beings with diabetes, pose a challenging assignment in healthcare due to their sluggish healing, higher chance of infection, and awful effectiveness of elegant treatments. Lately, redress the usage of plant-based treatment have received a true deal interest due to the fact of a range of restoration benefits. This look up desires to create and decide a new kind of transdermal patch made from latex extracted from Calotropis gigantea, a medicinal plant identified for its healing, anti-inflammatory, and antimicrobial effects, which need to be beneficial in treating diabetic wounds. The latex used to be meticulously extracted and blended into a biocompatible patch made from polyvinylpyrrolidone (PVP) and hydroxypropyl methylcellulose (HPMC). The patches have been definitely examined for a quantity of bodily and chemical properties, such as thickness, strength, durability, moisture levels, and pH. Studies on drug launch validated that the patches allowed for a regular and managed launch over time. To think about antibacterial properties, checks have been carried out in opposition to Staphylococcus aureus and Pseudomonas aeruginosa, which are frequent germs placed in diabetic wounds. The patches created essential inhibition zones of 18 mm and 21 mm, respectively. Further assessments the use of Franz diffusion cells validated first-class drug shipping by way of the skin, while compatibility checks on HaCaT human keratinocyte cells demonstrated that the latex used to be secure at therapeutic levels. These penalties spotlight the achievable of the usage of Calotropis gigantea latex-based transdermal patches for superb diabetic wound treatment. This formulation gives targeted drug transport alongside with sturdy antimicrobial houses and a proper protection profile. The findings encourage similarly research in living organisms and scientific trials to completely discover the therapeutic workable of this plant-based treatment.
Keywords: Calotropis gigantea, Transdermal patch, Diabetic wound, Antimicrobial, Wound healing
How to cite this article: Akilandeswari VG, Geetha G, Selvasudha N, Renosa sarun AM, Deepthi J, Dhivya sri N. Calotropis gigantea Latex-Based Transdermal Patch: Formulation, Characterization, and Evaluation for Diabetic Wound Infections. Int J Drug Deliv Technol. 2026;16(11s): 274-286; DOI: 10.25258/ijddt.16.11s.26
Source of support: Nil.
Conflict of interest: Nil