1Department of Physics, St. Joseph's College (Autonomous), Affiliated to the Bharathidasan University, Tiruchirappalli-620 002, Tamilnadu, India.
Corresponding author details:
Dr. G. Samuel, Assistant Professor, Department of Physics, St. Joseph's College (Autonomous), Tiruchirappalli – 620002, India.
E-mail: samuel_ph1@mail.sjctni.edu
This study investigates the impact of sonication on the physical, biochemical, and antimicrobial properties of Polyalthia longifolia leaf extracts and sugar solutions. Physical parameters, including density, viscosity, ultrasonic velocity, acoustic impedance, and adiabatic compressibility, were analyzed before and after sonication at 5, 10, and 15-minute intervals. Biochemical assays revealed progressive increases in protein and carbohydrate levels after sonication, indicating enhanced extraction efficiency. Structural modifications were confirmed using Fourier Transform Infrared (FTIR) spectroscopy, which showed changes in functional group intensities, and UV-visible spectroscopy, which revealed peak shifts indicative of cell disruption. Particle size analysis demonstrated a reduction in size, attributed to shear forces during sonication. Antimicrobial activity was assessed using the agar well diffusion method. Polyalthia longifolia extracts showed consistent activity against Enterococcus faecalis, with limited impact on Pseudomonas aeruginosa, while sugar solutions exhibited negligible antimicrobial effects. These findings highlight the potential of sonication to optimize the extraction of bioactive compounds and influence physical and structural properties. This method is particularly effective for enhancing molecular interactions and studying the structural transformations in complex biological systems. The study underscores sonication's utility in bioactive compound research and its applications in pharmaceuticals, food, and biotechnology.
Keywords: Sonication, Polyalthia longifolia, sugar solutions, biochemical properties, antimicrobial activity, FTIR spectroscopy.
How to cite this article: Samuel G, Mary JTT, Johnson I. Effects of Sonication on the Physical and Biochemical Properties of Polyalthia Longifolia Leaf Extracts and Sugar Solutions. Int J Drug Deliv Technol. 2026;16(11s): 398-403. DOI: 10.25258/ijddt.16.11s.38
Source of support: Nil.
Conflict of interest: None