1Assistant Professor, Department of AIDS, VSB Engineering College, Karur, India. Email: annabhar87@gmail.com
2Assistant Professor, Department of Chemistry, Agni college of technology, Thalambur, India. Email: rajitha.sh@act.edu.in
3Professor, Dept of computer science and Engineering, KGISL Institute of Technology Coimbatore, India. Email: thenmozhi.t@kgkite.ac.in
4Professor, Department of Mechatronics Engineering, Nehru Institute of Engineering and Technology, Coimbatore, India. Email: maheswaransastra@gmail.com
5Assistant Professor, Department of Computer Science and Design, Erode Sengunthar Engineering College, India. Email: kcpcsdesec@gmail.com
6Assistant Professor, Department of Computer Science and Engineering, VSB College of Engineering Technical Campus, Coimbatore, India. Email: ramadevivsbcse@gmail.com
Targeted drug delivery systems (TDDS) have become a revolutionary method in contemporary medicine, allowing drugs to be accurately targeted at the affected areas while reducing the side effects on the whole body. Nowadays, nanotechnology has played a huge role in creating the next generation of drug carriers including liposomes, polymeric nanoparticles dendrimers micelles, and solid lipid nanoparticles by making them more bioavailable, stable, and offering controlled drug release properties. These nanoscale carriers use passive targeting methods like the EPR (enhanced permeability and retention) effect while also relying on active targeting through ligand receptor interaction to localize drugs precisely at the disease site. In addition, the use of stimuli-responsive drug carriers that change their behaviour according to pH temperature enzymes, or redox also help in making therapy more accurate by unloading drugs at the diseased sites alone. A number of recent studies demonstrate dramatic therapeutic efficacy with targeted drug nanocarriers. For instance, antibody-conjugated Nano capsules led to a 4 times higher anticancer performance than drugs alone in animal models of pancreatic cancer. In the same vein, sophisticated nanonetwork-mediated transport systems enhanced the share of drug reaching the target cells by around 17%, whereas colon-specific nanoparticles were capable of encapsulating 83.5% of the drug and releasing 95.2% of it in the target area.
Keywords: Targeted Delivery, Nanocarriers Design, Drug Encapsulation, Controlled Release, Therapeutic Efficiency, Precision Medicine
How to cite this article: Bharathidhasan A, Radhakrishnan R, Thenmozhi T, Maheswaran M, Palanisamy KC, Ramadevi M. Recent Developments in Targeted Nanocarrier Drug Delivery for Improved Disease Treatment. Int J Drug Deliv Technol. 2026;16(11s): 423-428. DOI: 10.25258/ijddt.16.11s.42
Source of support: Nil.
Conflict of interest: None