1Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India
*Corresponding author: Sarita Bhandari, E-mail: saritabhandari1@gmail.com
Introduction: Biofilm forming from a variety of microbial pathogens can pose a serious health hazard that is difficult to combat. Nanotechnology, however, represents a new approach to fighting and eradicating biofilm forming microorganisms. Particularly, silver nanoparticles (AgNPs) have demonstrated exceptional bactericidal properties in a wide range of microorganisms, including some oral bacteria.
Aim: In the present study, the sustainable synthesis and characterization of biocompatible silver nanoparticles (AgNPs) from seed extracts of patchouli oil was explored.
Materials and method: Silver nanoparticles (AgNPs) doped with patchouli oil (Pogostemon cablin) were synthesized using a chemical reduction method. Briefly, an aqueous silver nitrate (AgNO₃) solution was used as the silver precursor, and patchouli oil was incorporated during the synthesis process to facilitate doping and enhance antimicrobial activity. The mixture was stirred under controlled temperature conditions until a visible color change indicated the formation of silver nanoparticles. The synthesized nanoparticles were then purified by centrifugation and washed with distilled water to remove unreacted components. The antibiofilm activity of the synthesized patchouli oil doped AgNPs was evaluated using standard biofilm inhibition assays against selected microbial strains. Biochemical analyses were conducted to assess microbial growth inhibition and biofilm formation. Additionally, the morphology and elemental composition of the synthesized nanoparticles were characterized using Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray Spectroscopy (EDX).
Conclusion: The present study demonstrates the potential of using plant-derived AgNPs to inhibit biofilm formation for therapeutic treatments that represent a new method of effectively treating a variety of infectious diseases caused by pathogenic microbes.
Keywords: Anti bioflim effect, Anti caries effect, Nanoparticles, Tooth decay
How to cite this article: Neha, Bhandari S, Uddin I. Exploring the anti biofilm effect of patchouli oil coated with silver nanoparticles for improved anti bacterial effect. Int J Drug Deliv Technol. 2026;16(11s): 514-519. DOI: 10.25258/ijddt.16.11s.52
Source of support: Nil.
Conflict of interest: None