1Senior Resident, Department of Pathology, J N Medical College and Hospital, AMU, Aligarh
2Professor, Department of Pathology, J N Medical College and Hospital, AMU, Aligarh
3Professor, Department of Pathology, J N Medical College and Hospital, AMU, Aligarh
4Professor, Department of Obstetrics and Gynaecology, J N Medical College and Hospital, AMU, Aligarh
*Corresponding author: Yusra Jamal, Email: yjamal.co@amu.ac.in, yusrajamal512@gmail.com
Pregnancy-induced hypertension (PIH) is the major cause of maternal and fetal mortality and morbidity and it contributes to 16% of mortality in pregnant mothers in developed and developing countries. Aim of this study was to estimate, evaluate and compare platelet count, prothrombin time (PT), activated partial thromboplastin time (APTT), D-Dimer and fibrinogen levels in patients with hypertensive disorders of pregnancy with normotensive pregnancies and further correlate the derangements in platelet count, PT, APTT, D-Dimer and fibrinogen levels with the clinical outcomes. For this a prospective case control study was conducted for two years in the Department of Pathology, JNMCH, AMU on total 128 pregnant females comprising of diagnosed cases of PIH and normal pregnant females were taken as controls. Platelet count, PT, APTT, D-Dimer and fibrinogen levels in 128 pregnant females (31 Severe Preeclampsia (BP above 160/110 mmHg), 37 Non-Severe Preeclampsia (BP ranges between 140/90 mmHg and 160/110 mmHg), and 60 Normal Pregnant Females) were evaluated and then correlated with the clinical outcomes. Analysis of variance (ANOVA) followed by post hoc Scheffe test has been used for statistical analysis. In this study, the mean platelet count significantly decreases while mean D-Dimer significantly increases with increasing severity of PIH. The mean PT, mean APTT and mean fibrinogen levels for the severe PIH group were significantly higher as compared to non-severe PIH and normal pregnancy groups. Statistical difference was not significant between the normal pregnancy group and the non-severe PIH group. Maternal and Fetal complications are more common with severe PIH, decreased platelet count and deranged coagulation profile. Therefore this study concludes that platelet count and D-dimer levels can be used to monitor the progression of pregnancy-induced hypertension and raised PT, APTT and fibrinogen levels are fairly good indicators of severe pregnancy-induced hypertension.
Keywords: PIH, Platelet count, PT, APTT, D-Dimer, Fibrinogen.
How to cite this article: Jamal Y, Arif SH, Hasan M, Mohsin Z. Comparative Study of Hypertensive Disorders of Pregnancy with Normotensive Pregnancies through Evaluation of Coagulation Profile and Platelet Count. Int J Drug Deliv Technol. 2026;16(11s): 520-536. DOI: 10.25258/ijddt.16.11s.53
Source of support: Nil.
Conflict of interest: None