1Professor, MNR College of Pharmacy, Sangareddy - 502294. Email: Srikanthreddyporeddy@gmail.com; ORCID: 0000-0002-9295-9213
2Assistant Professor, Government Pharmacy College Nalanda, B.M.I.M.S. Campus, Pawapuri, Nalanda. Email: piyushchandra001@gmail.com; ORCID: 0009-0005-2651-9913
3Institute of Pharmacy, Bundelkhand University (U.P). Email: Anadi1107@gmail.com; ORCID: 0009-0005-4290-6526
4Assistant Professor, Department of Psychology, Ferghana State University, 19, Murabbiylar street, Fergana city. Email: ganiyevakhalima@gmail.com; ORCID: 0009-0000-4650-4122
5Assistant Professor, Department of General Surgery, Ferghana Medical Institute of Public Health, Yangi Turon street 2A, Fergana. Email: doctoranx@gmail.com
6Department of Pharmaceutical Chemistry, Principal, MNR College of Pharmacy, Sangareddy, Telangana, India.
7Associate Professor, Department of Pharmaceutics, Sharda School of Pharmacy, Sharda University Agra, Agra, Uttar Pradesh, Pincode - 282007, India. ORCID: 0000-0003-2335-2570; Email: ritesh.kumar@agra.sharda.ac.in
*Corresponding author: Dr. Ritesh Kumar, Associate Professor, Department of Pharmaceutics, Sharda School of Pharmacy, Sharda University Agra, Agra, Uttar Pradesh, Pincode - 282007, India. ORCID: 0000-0003-2335-2570; Email: ritesh.kumar@agra.sharda.ac.in
Transdermal drug delivery systems have gained significant attention as an effective alternative to oral therapy due to their ability to bypass first-pass metabolism and provide controlled drug release. The present research focuses on the formulation and optimization of a transdermal patch containing anti-anxiety phytoconstituents extracted from medicinal plants traditionally used in the management of anxiety disorders. The selected phytoconstituents were characterized for compatibility with polymeric excipients prior to formulation. Transdermal patches were prepared using the solvent casting method with varying concentrations of polymers, plasticizers, and permeation enhancers. Optimization was carried out using a systematic experimental design to achieve desirable physicochemical properties. The prepared patches were evaluated for thickness, weight variation, folding endurance, moisture content, drug content uniformity, and in vitro drug release. Ex vivo permeation studies were performed using suitable animal skin to assess permeation behavior1. The optimized formulation demonstrated satisfactory mechanical strength, uniform drug distribution, and sustained release of phytoconstituents over an extended period. The findings suggest that the developed transdermal patch offers a promising, non-invasive, and patient-friendly approach for the delivery of anti-anxiety phytoconstituents, potentially improving therapeutic efficacy and patient compliance.
Keywords: Transdermal patch; Anti-anxiety; Phytoconstituents; Solvent casting method; Controlled drug delivery; Optimization; Herbal drug delivery system
How to cite this article: Reddy PS, Chandra P, Tiwari A, Akhmadkhanovna GK, ogli ANX, Alagarsamy V, Kumar R. Formulation and Optimization of a Transdermal Patch for Delivery of Anti-Anxiety Phytoconstituents. Int J Drug Deliv Technol. 2026;16(11s): 554-558. DOI: 10.25258/ijddt.16.11s.55
Source of support: Nil.
Conflict of interest: None