1Research scholar, Department of Pharmacy, Career Point University, Kota, Rajasthan, India. Email: ajawarkar@gmail.com
2Professor, Department of Pharmacy, Career Point University, Kota, Rajasthan, India. Email: manjumakhija12@gmail.com
*Corresponding author: Amol Jawarkar, Research scholar, Department of Pharmacy, Career Point University, Kota, Rajasthan, India. Email: ajawarkar@gmail.com
Due to rheumatoid arthritis' systemic inflammatory condition, ongoing pharmacologic treatment is necessary; however, traditional oral administration has potential for leading to undesired systemic side effects. Baricitinib is a very effective drug for the treatment of certain conditions because it selectively inhibits Janus kinase, but it can only be used for these conditions due to its metabolism by the liver and random distribution throughout the body. Engineering and establishing a topically applied nanoemulsion gel formulation consisting of Baricitinib were the focus of this research project as a method for treating specific areas. The nanoemulsion was prepared using a spontaneous emulsification technique with Transcutol® P as the oil phase and Tween 80–propylene glycol as the surfactant system.(1) All formulations were systematically optimized through the use of a ternary phase-mapping technique, and each formulation was then combined with a polymer matrix of Carbopol® 940. The optimized nanoemulgel exhibited nanoscale droplet size with narrow polydispersity, stable zeta potential, and skin-compatible pH. It also demonstrated pseudoplastic rheological behavior, uniform drug content, good spreadability, and sustained drug release for up to 12 hours following Korsmeyer–Peppas kinetics.(2) Studies of biological effectiveness using models of formaldehyde-induced arthritic challenges showed pronounced anti-edematous actions on a statistically comparable level as a policy comparison to benchmark-diclofenac formulations shown in previous research using formaldehyde challenged models. These findings suggest that the developed Baricitinib nanoemulsion gel is a promising topical delivery system for safer and effective management of rheumatoid arthritis.(3,4)
Keywords: Baricitinib; Nanoemulsion gel; Topical drug delivery; Rheumatoid arthritis management; JAK inhibition; Site-specific therapy; Controlled drug release; Inflammatory biomarkers
How to cite this article: Jawarkar A, Makhija M. Novel Baricitinib-Incorporated Nanoemulsion Gel: A Promising Topical Strategy For Enhanced Rheumatoid Arthritis Therapy. Int J Drug Deliv Technol. 2026;16(11s): 584-592. DOI: 10.25258/ijddt.16.11s.58
Source of support: Nil.
Conflict of interest: None