1Research Scholar, Department of Pharmaceutics, MGV's Pharmacy College, Panchavati, Nashik, Maharashtra 422003, India. Affiliated to Savitribai Phule Pune University, Pune, Maharashtra 411007, India. Email: shubhangi.albhar25@gmail.com; ORCID: 0000-0002-0454-2486
2Professor, Department of Pharmaceutics, Shreeshakti Shakshanik Sanstha Divine College of Pharmacy, Baglan, Nashik, Maharashtra 423301, India. Email: Deepak.sonawane999@gmail.com; ORCID: 0009-0007-3063-2032
3Professor, Department of Pharmaceutics, MGV's Pharmacy College, Panchavati, Nashik, Maharashtra 422003, India. Affiliated to Savitribai Phule Pune University, Pune, Maharashtra 411007, India. Email: pawarashish23@gmail.com; ORCID: 0000-0002-2532-7064
*Corresponding Author: Shubhangi N. Albhar, Research Scholar, Department of Pharmaceutics, MGV's Pharmacy College, Panchavati, Nashik, Maharashtra 422003, India. Email: shubhangi.albhar25@gmail.com; ORCID: 0000-0002-0454-2486
Objective: To develop mannose receptor-targeted Clofazimine nanoparticles incorporated into vaginal strips for localized treatment of female genital tuberculosis (FGTB), enhancing drug solubility, macrophage-specific uptake, site-specific delivery, and sustained release with minimal systemic toxicity.
Methods: Clofazimine nanoparticles were prepared and mannose-functionalized. Vaginal strips were formulated using Eudragit RL-100, Eudragit RS-100, HPMC K100M/E50, and PEG 400 via solvent casting. A 3-factor, 3-level Box–Behnken design optimized Eudragit RL-100, HPMC K4M, and magnetic stirring speed for thickness, folding endurance, and drug release. Evaluations included weight/thickness uniformity, folding endurance, surface pH, particle size, PDI, zeta potential, drug content, moisture content, swelling index, in-vitro drug release, SEM, DSC, and XRD.
Results: All strips exhibited uniform weight and thickness, good flexibility, and slightly acidic pH (3.83–4.47). Particle size ranged 80–97 nm (ST7: 80 nm), PDI 0.147–0.252, zeta potential −15.4 to −29.7 mV. Drug content (78.3–95%), moisture (4.25–8%), and swelling index (20.93–31.25%) were acceptable. In-vitro release was sustained over 8 h, with ST7 achieving 94.93% cumulative release. SEM showed uniform morphology; XRD indicated high crystallinity.
Conclusion: Mannose receptor-targeted Clofazimine strips exhibited consistent physicochemical properties, mechanical strength, and sustained release. ST7 demonstrated optimal size, stability, and macrophage targeting, providing a promising localized therapy for FGTB with reduced systemic toxicity.
Keywords: Female genital tuberculosis, Clofazimine, Mannose receptor, Nanoparticles, Vaginal strips
How to cite this article: Albhar SN, Sonawane DD, Pawar AY. Design And Development Of Mannose Receptor Targeted Strip Loaded Nano Formulation For Female Genital Tuberculosis. Int J Drug Deliv Technol. 2026;16(11s): 652-656. DOI: 10.25258/ijddt.16.11s.65
Source of support: Nil.
Conflict of interest: None