1Research Scholar, Department of Pharmaceutical Chemistry, Vinayaka Missions College of Pharmacy, Affiliated to Vinayaka Mission's Research Foundation (Deemed to be University), Ariyannoor, Salem, Tamil Nadu, India. Email: anoopckv85@gmail.com
2Professor, Department of Pharmaceutical Chemistry, Vinayaka Missions College of Pharmacy, Affiliated to Vinayaka Mission's Research Foundation (Deemed to be University), Ariyannoor, Salem, Tamil Nadu, India
*Corresponding Author: Mr. Anoop P, Research Scholar, Department of Pharmaceutical Chemistry, Vinayaka Missions College of Pharmacy, Affiliated to Vinayaka Mission's Research Foundation (Deemed to be University), Ariyannoor, Salem, Tamil Nadu, India. Email: anoopckv85@gmail.com
Diabetes mellitus (DM), which is categorized by abnormally raised Blood Glucose (BG) levels, is an international health crisis. Kyllinga nemoralis is a medicinal plant that has been utilized as a treatment for metabolic disorders, including diabetes; however, its chemical profile and potential anti-diabetic effects have yet to be evaluated comprehensively with modern analytical approaches. The current study assessed the ethanolic extract of K. nemoralis using High-Resolution Liquid Chromatography–Mass Spectrometry (HR-LCMS) to detect its constituents and its potential anti-diabetic and anti-oxidant effects. From the HR-LCMS analysis, nineteen bioactive constituents were identified that belonged to different phytochemical classes, including carbohydrates, phenols, flavonoids, tannins, saponins, alkaloids, steroids, terpenoids, and quinones. The extract also demonstrated concentration-dependent free radical scavenging activity, which confirmed its strong antioxidant potential. In vivo studies in diabetic Wistar rats showed that K.nemoralis extract decreased BG while promoting increased body weight. Moreover, in vitro experiments demonstrated anti-diabetic activity as evidenced by inhibition of α-amylase and α-glucosidase activity by the extract. In histopathological examinations, restoration of pancreatic tissue was noted for the treatment groups. These findings highlight the therapeutic potential of K. nemoralis as a natural source of bioactive compounds for developing plant-derived antidiabetic agents.
Keywords: Kyllinga nemoralis, Anti-diabetic activity, Phytochemical screening, HR-LCMS analysis, ethanolic extract.
How to cite this article: Anoop M, Umamaheswari D, Kumar M, Comprehensive Hr-Lcms-Based Characterization And Anti-Diabetic Assessment Of K.Nemoralis. .Int J Drug Deliv Technol. 2026; 16(11s): 819-829; DOI: 10.25258/ijddt.16.11s.83
Source of support: Nil.
Conflict of interest: None