International Journal Of Drug Delivery Technology
Volume 16, Issue 11s, 2026 | PG 999-1002

Neuroprotective Effects Of Mandragora Officinarum Leaf Extract Against Vincristine Induced Peripheral Neuropathy In Rats: Behavioral, Biochemical, And Histological Evidence

Rajinderpal Kaur1*, Ahmed Abdullah Khan2, Deepinderjeet Kaur1

1Research Scholar, Mulana Azad University, Jodhpur, India

2Research Supervisor, Mulana Azad University, Jodhpur, India

*Corresponding Author: Rajinderpal Kaur, Research Scholar, Mulana Azad University, Jodhpur, India. Email: krajinder280@gmail.com

ABSTRACT

Vincristine induced peripheral neuropathy (VIPN) is a common and debilitating side effect of chemotherapeutic regimens, characterized by pain, sensory deficits, oxidative stress, and inflammation. This study evaluated the protective potential of ethanolic extract of Mandragora officinarum leaves in a rat model of VIPN. Rats were administered vincristine (100 μg/kg/day, i.p.) to induce neuropathy and treated with M. officinarum extract (250 and 500 mg/kg, p.o.) or standard Methylcobalamin (50 μg/kg, i.p.). Neuropathic pain behaviors were assessed using hot plate, tail flick, and cold allodynia tests. Nerve conduction velocity (NCV), serum pro inflammatory cytokines (IL 6, IL 1β, TNF α), and antioxidant parameters (SOD, CAT, LPO, NO) were measured. Sciatic nerve histopathology was examined. Vincristine induced significant hyperalgesia, cold allodynia, reduced NCV, elevated pro inflammatory cytokines, and oxidative stress markers. Treatment with M. officinarum extract significantly ameliorated these effects, improving pain thresholds, NCV, reducing cytokine levels, restoring antioxidant status, and preserving nerve architecture. These findings suggest that M. officinarum leaf extract exerts neuroprotective effects against VIPN likely through anti inflammatory and antioxidant mechanisms, supporting its potential therapeutic application in chemotherapy induced neuropathy.

Keywords: Mandragora officinarum; vincristine; peripheral neuropathy; oxidative stress; pro inflammatory cytokines; nerve conduction velocity; neuroprotection

How to cite this article: Kaur R, Khan AA, Kaur D. Neuroprotective Effects of Mandragora officinarum Leaf Extract Against Vincristine Induced Peripheral Neuropathy in Rats: Behavioral, Biochemical, and Histological Evidence. Int J Drug Deliv Technol. 2026;16(11s): 999-1002. DOI: 10.25258/ijddt.16.11s.98

Source of support: Nil.

Conflict of interest: None