International Journal Of Drug Delivery Technology
Volume 16, Issue 12s, 2026 | PG 177-185

Antistress Biochemical And Histopathological Exploration Of Phytogenic Nanoformulation

Diksha Devi1*, Moumita Barman2, Priyanka Thakur3, Neha Sharma4, Deepika Singh5, Tamalika Chakraborty6

1LR College of Pharmacy, Solan, Himachal Pradesh

2I.T.S College of Pharmacy, Ghaziabad, Uttar Pradesh

3Department of Pharmacology, University School of Pharmaceutical Sciences, Rayat Bahra University, Mohali, Punjab 140301

4GHG Institution of Pharmacy, Sidhwan Khurd, Ludhiana, Punjab

5Department of Pharmaceutics, School of Pharmacy, BBD University, Lucknow 226028

6Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F Nilgunj Road, Sodepur, Panihati, Kolkata 700114

*Corresponding Author: Diksha Devi, LR College of Pharmacy, Solan, Himachal Pradesh. Email: dikshasambyal91@gmail.com, priyanka123thakur123@gmail.com

ABSTRACT

Depression is one of the most common mental health disorders affecting millions worldwide, often leading to serious emotional and physical distress. Traditional plant-based remedies have gained attention as safer alternatives to conventional medications. In this study, we investigated the anti-depressant potential of biosynthesized silver nanoparticles (Ag-NPs) derived from Cissampelos pareira leaf extracts. Using a green synthesis method, Ag-NPs were prepared and characterized. Their effects were evaluated in a rodent model of depression using behavioral tests (Force Swim Test), biochemical markers of oxidative stress, and brain histology. The results demonstrated that Cissampelos pareira-derived Ag-NPs significantly reduced depression-like behaviors, lowered oxidative stress levels, and showed protective effects on brain tissues. These findings suggest that green-synthesized Ag-NPs from Cissampelos pareira may represent a promising natural therapeutic approach for managing depression.

Keywords: Depression, Cissampelos pareira, Silver Nanoparticles, Green Synthesis, Force Swim Test, Oxidative Stress.

How to cite this article: Devi D, Barman M, Thakur P, Sharma N, Singh D, Chakraborty T. Antistress Biochemical and Histopathological Exploration of Phytogenic Nanoformulation. Int J Drug Deliv Technol. 2026;16(12s): 177-185. DOI: 10.25258/ijddt.16.12s.19

Source of support: Nil.

Conflict of interest: None