1Junior Resident, Department of E.N.T., Malkapur, Karad (Dist. Satara), Maharashtra, India. Email: dr.sjvigneshwar@gmail.com; ORCID: 0009-0000-8094-6995
2Professor & Head, Department of E.N.T., Malkapur, Karad (Dist. Satara), Maharashtra, India. Email: abhayhavle@yahoo.co.in
3Assistant Professor, Department of E.N.T., Malkapur, Karad (Dist. Satara), Maharashtra, India. Email: swetacolvin@gmail.com
4Associate Professor, Department of Anatomy, Malkapur, Karad (Dist. Satara), Maharashtra, India. Email: swapna.shedge@gmail.com
5Junior Resident, Department of E.N.T., Malkapur, Karad (Dist. Satara), Maharashtra, India. Email: mp.adi1405@gmail.com
6Junior Resident, Department of E.N.T., Malkapur, Karad (Dist. Satara), Maharashtra, India. Email: rajeshhugar15@gmail.com
7Junior Resident, Department of Dermatology, Malkapur, Karad (Dist. Satara), Maharashtra, India. Email: prajaktasharma1997@gmail.com
*Corresponding Author: Dr Vigneshwar S J, Junior Resident, Department of E.N.T., Malkapur, Karad (Dist. Satara), Maharashtra, India. Email: dr.sjvigneshwar@gmail.com
Background: The powerful elastic fibers of platelet-rich fibrin, which are rich in growth components, make it the ideal patch material for tympanic membrane perforation. On this basis, this study set out to assess the efficacy of fibrin in myringoplasty in terms of the success rate of temporalis fascia graft uptake, as well as its safety.
Methods: This randomized controlled trial was conducted in the department of ENT in a tertiary care teaching hospital among patients who attended ENT department with large tympanic membrane perforation. A total of sixty six participants with COM were included in the study and all were included in the post treatment assessment. Cases were divided in two groups A (control group without fibrin sealant) and group B (fibrin sealant) using computer generated random numbers with 33 cases in each group. Ethical committee approval was obtained for this study. Data was analyzed using statistical package for social sciences.
Results: On comparing the groups – Myringoplasty with temporalis fasica graft using fibrin glue and Myringoplasty with temporalis fasica graft without using fibrin glue both the groups were similar in demographic and ontological findings. Notably the graft up-take was reported to be high in the group - Myringoplasty with temporalis fasica graft using fibrin glue compared to non fibrin glue group. However, postop grading of hearing loss, and postop mean ABG were similar in both Myringoplasty with temporalis fasica graft using fibrin glue and Myringoplasty with temporalis fasica graft without using fibrin glue. Additionally, in both groups, on comparing pre and postop hearing loss, pre and postop mean ABG, the post op hearing and ABG were improved significantly.
Conclusion: By applying fibrin glue to the graft's borders and the perforation edges during myringoplasty, we may conclude that the temporalis fascia graft's success rate has significantly increased. Successful audiological outcomes and improved graft uptake following TM perforation are provided by the application of fibrin glue.
Key words: Perforation in ear, otitis media, surgical repair, fibrin glue
How to cite this article: Vigneshwar SJ, Havle AD, Colvin S, Shedge SA, P AM, Hugar R, Sharma PA. Myringoplasty with and without Fibrin Sealant use in Large Size Tympanic Membrane Perforation - A Comparative Study. Int J Drug Deliv Technol. 2026;16(12s): 248-254. DOI: 10.25258/ijddt.16.12s.26
Source of support: Nil.
Conflict of interest: None