1Associate Professor, Department of Pharmaceutical Analysis, Santhiram College of Pharmacy (Autonomous), Nandyal-518501, A.P. Email: maheswari.kukutla@gmail.com
2Professor, Department of Pharmaceutical Analysis, Santhiram College of Pharmacy (Autonomous), Nandyal-518501, A.P. Email: muneer.pharma@gmail.com
3Associate Professor, Department of Pharmaceutical Analysis, Santhiram College of Pharmacy (Autonomous), Nandyal-518501, A.P. Email: ruthmanorma5@gmail.com
4Associate Professor, Department of Pharmaceutical Analysis, Santhiram College of Pharmacy (Autonomous), Nandyal-518501, A.P. Email: chintalaparimaladevi@gmail.com
5Department of Pharmaceutical Analysis, Santhiram College of Pharmacy (Autonomous), Nandyal-518501, A.P. Emails: Vaishnavichalla8@gmail.com (C. Vaishnavi); deshampujitha2005@gmail.com (D. Pujitha); pothurajusravani92@gmail.com (P. Sravani); goddivelugalamounika@gmail.com (G. Mounika); malavikatene@gmail.com (T. Malavika)
*Corresponding Author: K. Maheswari, Associate Professor, Department of Pharmaceutical Analysis, Santhiram College of Pharmacy (Autonomous), Nandyal-518501, A.P. Email: maheswari.kukutla@gmail.com
A simple, sensitive, and selective UV Spectrophotometric method was successfully developed and validated for the estimation of OXACEPROL. The techniques utilized UV spectrometry, with the maximum absorbance (λmax) observed at 211 nm. The optimized concentration was determined to be 20 ng/ml, corresponding to an absorbance of 0.557. The assay method demonstrated excellent validation parameters, with a linearity coefficient of 0.9993. Precision and accuracy obtained a %RSD of less than 2, while recovery studies yielded results within the range of 98-102% (%RSD). Various stability studies, including LOQ, LOD,& robustness, confirmed the method's reliability, with LOD & LOQ values below 10. Robustness testing of % assay results ranging from 98-102%. Stability studies indicated the method remained stable under various conditions, and degradation studies under acidic and basic environments revealed less than 10% degradation, with % assay values maintained between 98-102%. The method was also effectively applied to the routine analysis of oxaceprol using UV spectrophotometry, where LOD and LOQ values were determined to be 1.21 ng/ml and 3.68 ng/ml.
Keywords: Oxaceprol, UV Visible spectroscopy, method development, Validation Parameters, stability studies
How to cite this article: Maheswari K, Muneer S, Manorama M, Devi P, Vaishnavi C, Pujitha D, Sravani P, Mounika G, Malavika T. A Novel UV Spectroscopic Stability Indicating Method Development and Validation for the Estimation of Oxaceprol API and its Pharmaceutical Formulation. Int J Drug Deliv Technol. 2026;16(12s): 359-364. DOI: 10.25258/ijddt.16.12s.40
Source of support: Nil.
Conflict of interest: None