1M.B.B.CH, Ophthalmology, Faculty of Medicine, Assiut University, Assiut, Egypt
2Professor of Ophthalmology Department, Faculty of Medicine, Cairo University, Kasr Al-Aini Hospital, Giza, Egypt
3MD, MRSC Edinburgh, Consultant of Ophthalmology, National Eye Center, Cairo, Egypt
4Lecturer of Ophthalmology, Faculty of Medicine, October 6 University, Giza, Egypt
*Corresponding Author: Sara Osman Mohamed Elnady Ellisy, M.B.B.CH, Ophthalmology, Faculty of Medicine, Assiut University, Assiut, Egypt
Background: Myopic choroidal neovascularization (CNV) can cause vision loss but responds well to early Anti-VEGF treatment Optical coherence tomography (OCT) is essential for diagnosing and monitoring CNV and Wet Age-Related Macular Degeneration (AMD). The aim of this work was to compare OCT features between myopic CNV and wet AMD patients and to investigate the relationship between OCT features and visual acuity in both conditions.
Methods: This prospective cross sectional study non-interventional comparative study was carried out on 48 eyes from 48 patients, divided into two groups: a myopic CNV group (≥18 years, −5.00 to −10.00 diopters, recent active CNV confirmed by OCT and fundus exam) and a wet AMD group (>50 years, recent active neovascular AMD with exudative features on OCT), with all patients having clear ocular media for adequate imaging.
Results: In the Myopic NV group, cystoid edema showed a moderate positive correlation with central choroidal thickness (r = 0.404, P=0.050). Other retinal findings showed weak or no correlation. In contrast, the Wet AMD group displayed weak or non-significant correlations between retinal and choroidal findings, with no significant associations, suggesting that retinal characteristics have little influence on choroidal thickness in this group.
Conclusions: The significant choroid-retinal correlations in myopic CNV emphasize the choroid's key role, suggesting routine choroidal thickness measurement in OCT evaluations for macular neovascularization.
Keywords: Comparative Analysis, Optical Coherence Tomography, Myopic Choroidal Neovascularization, Macular Degeneration
How to cite this article: Gburi MS, Hussein EA, Mohammed RA and Hassan IT, Comparative Analysis of Optical Coherence Tomography Features in Myopic Choroidal Neovascularization and Wet Age-related Macular Degeneration. Int J Drug Deliv Technol. 2026;16(12s): 384-391. DOI: 10.25258/ijddt.16.12s.43
Source of support: Nil.
Conflict of interest: None