1Research Scholar, School of Pharmaceutical Sciences, CT University, Ludhiana-142024, Punjab, India. Email: noelchemistry@gmail.com
2*Associate Professor, School of Pharmaceutical Sciences, CT University, Ludhiana-142024, Punjab, India. Email: amansatnamgill@gmail.com
3Professor, Head of Department, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Punjab. Email: monikaguptaa@gmail.com
4Professor & Head, Department of Pharmacology, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela 140111 Ropar, Punjab, India (An Autonomous College). Email: kushwah_ph05@yahoo.co.in; Institutional Email: ajay@copbela.org; ORCID: 0000-0003-0559-7670
*Corresponding Author: Dr. Amandeep Kaur Gill, Associate Professor, School of Pharmaceutical Sciences, CT University, Ludhiana-142024, Punjab, India. Email: amansatnamgill@gmail.com
Background: Though the plant has not been thoroughly studied to support its traditional claims, Alternanthera pungens (Kantevalisanti; Amaranthaceae) has been used traditionally to treat a variety of illnesses, primarily anxiety. Therefore, it was intended to use the elevated plus maze model (EPM) to examine the antianxiety properties of different extracts and fractions of Alternanthera pungens aerial parts.
Methods: The aerial components of Alternanthera pungens that were correctly identified were extracted in a methodical and thorough manner utilizing solvents in ascending order of polarity, namely n-hexane, chloroform, methanol, and water using Soxhlet technology. The antianxiety effects of all phytochemical-rich crude extracts were tested in mice at dosages of 100, 200, or 400 mg/kg, p.o. Alternanthera pungens' effectiveness was statistically contrasted with that of diazepam, a common anxiolytic medication (2 mg/kg, i.p.). At a dose of 400 mg/kg, the methanol extract was statistically equal to the standard medication and showed considerable antianxiety action when compared to the control. There was some moderate antianxiety action in the chloroform extract. n-hexane, ethyl acetate, and 1-butanol were the solvents used to partition the bioactive methanol extract in ascending order of polarity. All fractions rich in phytochemicals were tested for antianxiety effects in mice at dosages of 25 or 50 mg/kg, p.o.
Results: At a dose of 50 mg/kg, only the ethyl acetate fraction demonstrated considerable antianxiety effect comparable to the standard medication.
Conclusion: Current research has scientifically confirmed Alternanthera pungens' traditional claims of antianxiety properties. It has been proposed that phenolic and flavonoid chemicals found in the aerial sections of Alternanthera pungens may help alleviate anxiety problems.
Keywords: Alternanthera pungens, Anxiolytic, Diazepam, Elevated plus maze, Flavonoids.
How to cite this article: Mankoo N, Gill AK, Gupta M, Kushwah AS. Evaluation of Antianxiety Profile of Alternanthera pungens Aerial Parts. Int J Drug Deliv Technol. 2026;16(12s): 715-720. DOI: 10.25258/ijddt.16.12s.85
Source of support: Nil.
Conflict of interest: None