1Research Scholar, Maharishi School of Pharmaceutical Sciences, Maharishi University of Information Technology, Sitapur road, Lucknow, Uttar Pradesh, India. Email: sakshi.y0901@gmail.com; ORCID: 0009-0001-2061-3264
2Professor, Maharishi School of Pharmaceutical Sciences, Maharishi University of Information Technology, Sitapur road, Lucknow, Uttar Pradesh, India. Email: rawataks@rediffmail.co; ORCID: 0000-0003-0559-3346
*Corresponding Author: Sakshi, Research Scholar, Maharishi School of Pharmaceutical Sciences, Maharishi University of Information Technology, Sitapur road, Lucknow, Uttar Pradesh, India. Email: sakshi.y0901@gmail.com
Background: Topical drug delivery systems based on nanotechnology have gained increasing attention due to their enhanced bioavailability, controlled drug release, and improved patient compliance. Silver nanogels, combining the antimicrobial potential of silver nanoparticles with the biocompatibility of gel matrices, represent a promising platform for topical therapeutic applications.
Objective: The present study aimed to formulate silver nanogels using ethanolic, hexane, and hydroalcoholic extracts of different parts (seed, leaf, and bark) of Delonix elata and Delonix regia, followed by comprehensive physicochemical evaluation and stability assessment for topical delivery.
Methods: Silver nanogels were formulated using plant-mediated silver nanoparticles incorporated into a gel base. A total of eighteen formulations were prepared and evaluated for physicochemical parameters including pH, viscosity, spreadability, homogeneity, drug content, and entrapment efficiency. Stability studies were conducted under different storage conditions as per standard guidelines to assess formulation robustness over time.
Results: All formulated silver nanogels exhibited acceptable physicochemical properties suitable for topical application. The pH values were within the skin-compatible range, while viscosity and spreadability profiles indicated good applicability and consistency. Stability studies demonstrated minimal changes in physicochemical parameters, indicating good formulation stability. Formulations prepared using hydroalcoholic and hexane extracts showed comparatively superior physicochemical stability.
Conclusion: The study concludes that silver nanogels derived from Delonix elata and Delonix regia possess favorable physicochemical characteristics and stability, making them promising candidates for topical drug delivery applications. These plant-based silver nanogels provide a stable, biocompatible, and effective platform for future therapeutic use.
Keywords: Silver nanogels, Delonix elata, Delonix regia, Topical delivery, Physicochemical evaluation, Stability analysis, Plant-mediated synthesis
How to cite this article: Sakshi, Rawat AKS. Formulation, Physicochemical Evaluation and Stability Analysis of Silver Nanogels Derived from Delonix elata and Delonix regia for Topical Delivery. Int J Drug Deliv Technol. 2026;16(12s): 810-815. DOI: 10.25258/ijddt.16.12s.95
Source of support: Nil.
Conflict of interest: None