1Ph. D Research Scholar, Pharmaceutical Sciences, Nims Institute of Pharmacy, Jaipur, Rajasthan, India
2Department of Pharmaceutical Sciences, Genesis Institute of Pharmacy, Radhanagari, Kolhapur, Maharashtra, India
3Department of Pharmaceutical Sciences, Nims Institute of Pharmacy, Jaipur, Rajasthan, India
4Department of Pharmaceutical Sciences, Vasantidevi Patil Institute of Pharmacy, Kodoli, Kolhapur, Maharashtra, India
*Correspondence Author: Nilam Uttam Metkari. Email: nilamtkcp1994@gmail.com
Objective: The aim of the study is to explore the formulated bilayer tablets using both novel and conventional polymers to enhance antimicrobial efficacy. By combining immediate-release and sustained-release layers, the tablets aim to deliver rapid and prolonged therapeutic action.
Methods: Active pharmaceutical ingredients known for their antimicrobial properties were incorporated and evaluated for physical characteristics, drug release behavior, and microbiocidal activity.
Results: Novel polymers demonstrated superior control over drug release and significantly improved antimicrobial potency, especially against Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. Biochemical tests confirmed the pathogenic traits of the isolates, while biofilm inhibition assays revealed enhanced disruption by novel polymer-based formulations. Stability and compatibility studies further supported the reliability of these systems.
Conclusion: Overall, the findings highlight the potential of bilayer tablets with innovative polymers as a promising approach for targeted and sustained antimicrobial therapy in urinary tract infections.
Key words: Biofilm inhibition, Bilayer tablet formulation, Novel polymers, Microbicidal activity.
How to cite this article: Metkari NU, Chawra HS, Manjappa AS. Dual-Polymer Bilayer Tablets for Enhanced Drug Delivery and Prolonged Microbiocidal Effect. Int J Drug Deliv Technol. 2026;16(13s): 930-936. DOI: 10.25258/ijddt.16.13s.106.
Source of support: Nil.
Conflict of interest: None