1Assistant Professor, School of Pharmacy, Vishwakarma University, Survey No 2,3,4 Laxmi Nagar, Kondhwa, Budruk, Pune 411048. Maharashtra. Email: dipalitalele93@gmail.com
2*Assistant Professor, Amity Institute of Pharmacy, Amity University Maharashtra, Mumbai 410206, Maharashtra, India. Email: raghuwanshineha53@gmail.com (Corresponding Author)
3Principal, Dr. R. G. Bhoyar Institute of Pharmacy, Seloo, Wardha, Nagpur. Email: rgbip_pva@rediffmail.com
4Assistant Professor, Shree K.R. Pandav Institute of Pharmacy, dighori naka, bahadura umred road, nagpur 440034 Maharashtra. Email: Kavi.mane212@gmail.com
5Associate Professor, Faculty of Pharmaceutical Sciences, Rama University Mandhana Kanpur Uttar Pradesh, 209217. Email: prashants845@gmail.com
6Associate Professor, St. George Institute of Pharmacy, Raisen Bhopal (M.P). Email: mishra.priyanka0412@gmail.com
7Assistant Professor, Jagran School of Pharmacy, Bhopal, MP, India, 462044. Email: Khanabdulaali@gmail.com
8Assistant Professor, St. George Institute of Pharmacy, Raisen Bhopal (M.P). Email: sona1997p@gmail.com
Objective: The present study was aimed at the development and evaluation of rosiglitazone-loaded floating microspheres as a gastroretentive drug delivery system to enhance gastric residence time and sustain drug release. Floating microspheres were prepared using the emulsion solvent diffusion–evaporation technique employing ethyl cellulose and hydroxypropyl methylcellulose (HPMC) as polymeric carriers. The prepared formulations were evaluated for percentage yield, particle size, entrapment efficiency, buoyancy, surface morphology, and in vitro drug release.
Results: The percentage yield of microspheres ranged from 72.4 ± 2.1% to 89.6 ± 1.8%, while particle size varied between 210 ± 12 µm and 385 ± 18 µm. Entrapment efficiency was found to be in the range of 68.3 ± 2.5% to 91.2 ± 1.6%. In vitro buoyancy studies indicated that the optimized formulation (F3) exhibited maximum buoyancy of 93.4 ± 1.7% and remained floating for more than 12 hours. Drug release studies demonstrated sustained release behavior with cumulative drug release of 94.5 ± 2.1% over 12 hours.
Kinetic Modeling: Kinetic modeling revealed that the drug release followed the Higuchi model (R² = 0.987), indicating diffusion-controlled release, while the Korsmeyer–Peppas model suggested non-Fickian diffusion (n = 0.74). Statistical analysis confirmed that formulation variables had a significant effect on all evaluated parameters (p < 0.05).
Conclusion: The study concludes that rosiglitazone-loaded floating microspheres represent a promising gastroretentive system capable of enhancing drug bioavailability and providing sustained therapeutic action.
Keywords: Rosiglitazone, Floating microspheres, Gastroretentive drug delivery, Sustained release, Higuchi model
How to cite this article: Talele D, Raghuwanshi N, Thakre SM, Mane KR, Singh PK, Mishra P, Khan MAA, Prajapati S. Development and Evaluation of Rosiglitazone-Loaded Floating Microspheres as a Gastroretentive Drug Delivery System. Int J Drug Deliv Technol. 2026;16(13s): 145-152. DOI: 10.25258/ijddt.16.13s.15
Source of support: Nil.
Conflict of interest: None