1Research Scholar, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad- Delhi Road, 244001. India
2Professor and Principal, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad- Delhi Road, 244001. India
3Professor, PSIT-Pranveer Singh Institute of Technology (Pharmacy), Kalpi Road, Bhauti, Kanpur-209305. India
Corresponding Author: Mr. Rishabh Maurya, Research Scholar, Teerthanker Mahaveer College of Pharmacy (TMCOP), Teerthanker Mahaveer University (TMU), Delhi Road, Moradabad, Uttar Pradesh (244001), India. Email: mirishabh14@gmail.com
A new RXN nanoemulgel based on carbopol 934 was created to be used in intra-pocket periodontal therapy that has to provide better retention and the delivery of the drug to the target area. Spontaneous emulsification generated RXN nanoemulsions with the excipients: oil phase (eugenol), surfactant (Tween 80), co-surfactant (PEG 400), aqueous phase (water). A Box–Behnken experimental design (3-factor, 3-level) was utilized to optimize the formulation in which the concentration (v/v) of oil (X1), Smix surfactant and co-surfactant (X2), and water (X3) were the independent variables. The dependent variables were to be optimized by globule size (Y1), heterogeneity index /polydispersity index (PDI) (Y2), and zeta potential (Y3). Globe size, PDI, zeta potential, viscosity and morphology of surface of the nanoemulsions were characterised and the developed nanoemulgel was also tested with content of drug, pH, mucoadhesion strength, on syringeability, temperature of sol-gel transition, viscosity and release of drug. The optimized formulation was 13% (oil), 37% (Smix) and 50 % (water) and that provided a globule size 118.3 ± 7 nm, PDI 0.387 ± 0.023 and zeta potential -21.73 ± 5.67 mV. The analysis of surface morphology and globule size done by transmission electron microscopy (TEM) disclosed the optimized nanoemulgel had mainly uniform and spherical particles diameter (22.10 to 180.10 nm). The optimized RXN nanoemulgel was found to have good syringeability and an appropriate viscosity, and sol-gel transition, which makes it easy to apply intra-pocket. It demonstrated a sustained release of the drug in ex-vivo and a high antibacterial effect of S. aureus (24.1 ± 0.34 mm) and E. coli (18.7 ± 0.36 mm). These findings affirm its ability as a useful localized drug delivery in periodontal therapy.
Keywords: Periodontitis, Periodontal drug delivery system (PDDS), Nanoemulsion, Polydispersity Index, Zeta potential
How to cite this article: Maurya R, Mittal A, Tiwari G. Formulation, Optimization & Evaluation of Nanoemulgel Loaded with Roxithromycin and Eugenol for Effective Periodontitis Management. Int J Drug Deliv Technol. 2026;16 (13s): 8-33; DOI: 10.25258/ijddt.16.13s.2
Source of support: None
Conflict of interest: None