1Student, Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India. Email: neha.ranga6222@gmail.com
2*Assistant Professor, Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India. Email: vaishnavir.sdc@saveetha.com (Corresponding Author)
3Professor, Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India. Email: padma@saveetha.com
4Associate Professor, Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India. Email: saravanans.sdc@saveetha.com
Aim: This study aims to evaluate Soft Tissue Compatibility of Hafnium-Coated Titanium Implants through Human Gingival Fibroblast Cell Lines in an in vitro environment. The focus of this research is on assessing cell morphology, cell viability, proliferation, adhesion and impact of hafnium coating on implant integration.
Materials & Methods: The study utilized titanium micro screws as the control group and hafnium oxide-coated titanium micro screws as the test group. Fibroblast cells were cultured in both groups to assess cell viability and proliferation using MTT assays, and osteoblastic differentiation was evaluated.
Results: Hafnium-coated titanium micro screws demonstrated higher levels of osteogenic markers, including BMP-2, ALP, and Runx2, compared to uncoated screws. Both groups exhibited similar biocompatibility using the MTT assay, with no cytotoxic effects on the osteoblast cells. However, the hafnium coating significantly enhanced cell proliferation and differentiation, suggesting improved osteogenic potential.
Conclusion: Hafnium oxide-coated titanium micro screws significantly improve osteoblastic activity in vitro, showing potential for enhanced osseointegration in clinical applications. The results indicate that the hafnium coating enhances osteoblast differentiation and bone formation, making it a promising material for orthopedic and dental implants.
Keywords: hafnium oxide, titanium, micro screws, nanoparticles, osteoblastic activity, HGF cell line, osseointegration, surface modification, MTT assay.
How to cite this article: Neha R, Rajaraman V, Ariga P, Sekaran S. Investigating the Soft Tissue Compatibility of Hafnium-Coated Titanium Implants through Human Gingival Fibroblast Cell Lines. Int J Drug Deliv Technol. 2026;16(13s): 230-235. DOI: 10.25258/ijddt.16.13s.24
Source of support: Nil.
Conflict of interest: None